规格: | 5mg | 产品价格: | 609 |
---|
规格: | 10mg | 产品价格: | 1155 |
---|
规格: | 50mg | 产品价格: | 4872 |
---|
Catalog Number 14704
Synonyms AR 014418|AR 0133418|Glycogen Synthase Kinase 3β Inhibitor VIII|SN 4521
Molecular Formula C12H12N4O4S
Relative Molecular Mass 308.3
CAS Registry Number 487021-52-3
Formulation A crystalline solid
λmax 226, 275, 348, 353 nm
Purity ≥98%
Storage -20°C
SMILES O=C(NCC1=CC=C(OC)C=C1)NC2=NC=C([N+]([O-])=O)S2
产品描述
GSK3β Inhibitor VIII is an ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3β (Ki = 38 nM; IC50 = 104 nM). It does not significantly inhibit the closely related cyclin-dependent kinase (Cdk)2 or Cdk5 (Kis = > 100 μM). GSK3β Inhibitor VIII demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC50 = 2.7 μM) at a GSK3-specific site (Ser396) in cells stably expressing human four-repeat tau protein and also by protecting β-amyloid-exposed N2A neuroblastoma cells against cell death.
更多产品信息,请点击:https://www.caymanchem.com/product/14704原装进口,Fmoc-D-Biocytin,Cayman品Pai大包装更优惠!
Cayman公司成立于1980年,在过去20多年的发展过程中,始终保持着为科研工作者提供高质、优价研究产品的宗旨。该公司目前可以提供13,138 多种生化和免疫试剂,涉及肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等研究领域。非常有特色的检测试剂盒包括类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等。


温馨提示:不可用于临床ZL。