EGFR|EGFR单抗|EGFR antibody

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基本信息

中文名称:小鼠抗人表皮生长因子受体/EGFR单抗

英文名称:Mouse anti- Human Epidermal growth factor receptor monoclonal antibody

货号:CSB-MA102771A0m

别名:Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1

详细数据

产品类型:Monoclonal antibodies

规格:100ug

免疫原:Recombinant Human Epidermal growth factor receptor

宿主:Mouse

种属反应性:Human,Other species are not tested.Please decide the specificity by homology

背景:

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.

克隆类型:monoclonal

抗体亚型:IgG1

保存缓冲液:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

储存条件:Shipped at 4°C Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

纯化方式:Caprylic Acid Ammonium Sulfate Precipitation purified

标记方式:Non-conjugated

产品提供形式:liquid