WZ4002 1213269-23-8_详细资料

产品信息

WZ4002上海惠诚生物为广大科研用户提供科学仪器，试剂耗材等专业科研产品服务。
代理产品品Pai有：Nu-chek、LKT、AccuStandard、APSC、MPBio、Sigma-Aldrich、NIST，Reagecon、Megazyme，LGC、Ultra，日本和光（WAKO）、Shodex，Dr.E、PSS ，Matreya，CaroteNature，瑞典Larodan产品等。
提供美国药典USP 、欧洲药典标 EDQM、加拿大TRC标准物质等，专业提供中草药单体标准品，HPLC 98%以上，20mg/瓶，及500mg、1g定制询价
联系人：吕小姐联系电话：021-60496554，联系QQ：2303607288White PowderWhite Powder

Description

WZ4002 inhibits EGFR in a variety of cell lines, including those harboring the T790M gatekeeper mutation. WZ2004 exhibits anticancer chemotherapeutic activity, inhibiting proliferation of lung adenocarcinoma cells and suppressing tumor growth in animal models.

Specifications

Cas No. 1213269-23-8

Product ID W9600

Product Name WZ4002

Formula C25H27ClN6O3

Formula Wt. 494.97

Purity ≥98%

Store Temp -20°C

References Nakagawa T, Takeuchi S, Yamada T, et al. Combined therapy with mutant-selective EGFR inhibitor and Met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung cancer. Mol Cancer Ther. 2012 Oct;11(10):2149-57. PMID: 22844075.

Sakuma Y, Yamazaki Y, Nakamura Y, et al. WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. Lab Invest. 2012 Mar;92(3):371-83. PMID: 22157722.

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