性能描述
纯度 |
≥97% |
solubility |
acetic acid: water (1:1): soluble50 mg/mL |
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by opening the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
地西他滨为目前已知的DNA甲基化特异性YZ剂,阻断DNA甲基化可致基因激活与诱导细胞分化。其对L1210的细胞毒作用可为胸苷所加强,是因胸苷可使本品掺入DNA的量增加,从而增加本品对DNA甲基化的YZ作用。本品为S期细胞周期特异性药物。
Preparation Instructions
This product is typically dissolved at 50 mg/ml in 50% acetic acid. This product is also soluble at 50 mg/ml in DMSO or 0.25 mg/ml in water.