About this Antibody |
Name | Wilms Tumor Protein Rabbit Monoclonal Antibody |
Category | Rabbit Monoclonal Antibody (RabMAb); Primary antibody |
Isotype | IgG |
Purification | Affinity purification |
About the Immunogen |
Immunogen | Recombinant protein |
Gene ID | 7490(Human); 22431(Mouse) |
SwissProt | P19544(Human); P22561(Mouse) |
Synonyms | AWT1; EWS-WT1; GUD; NPHS4; WAGR; WIT-2; WT33 |
Category | Cancer Biology |
Background | Wilms' tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and, like retinoblastoma, is observed in both sporadic and inherited forms. The Wilms' tumor locus has been mapped at chromosome 11p13 as a tumor suppressor gene which encodes a DNA binding protein with four zinc fingers and a glutamine-proline rich amino-terminus. The Wilms' tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators. However, in contrast to Egr transcription factors, WT1 behaves as a transcriptional repressor in transient transfection assays with synthetic promotor constructs. |