核转录因子NF-κB受体抗体(核因子kB受体活化因子)说明书_详细资料

产品信息

保存条件： Store at -20 °C 浓度： 1mg/1ml 应用范围： WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 形态：详见说明书亚型： IgG 免疫原： KLH conjugated synthetic peptide derived from human RANK C-terminus 适应物种：详见说明书宿主：详见说明书标记物：详见说明书抗体名：核转录因子NF-κB受体抗体(核因子kB受体活化因子) 抗体英文名： Anti-RANK/CD265 保质期：详见说明书抗原来源： Rabbit 克隆性：多克隆目录编号：详见说明书级别：详见说明书靶点：详见说明书数量： 52 供应商：上海一研规格： 0.2ml/200μg0.1ml/100μg 0.2ml/200μg

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英文名称 Anti-RANK/CD265
中文名称 核转录因子NF-κB受体抗体(核因子kB受体活化因子)说明书
别名 TNFRSF11A; CD265; CD265 antigen; Activator of NFKB; EOF; FEO; mRANK; NFKB activator; ODFR; OFE; Osteoclast differentiation factor receptor; PDB 2; Receptor activator of NF KB; receptor activator of nuclear factor kappa B; TNFRSF 11A; TNFSF11; TRANCE R; RANK receptor.
浓度 1mg/1ml
规格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat
产品类型一抗
研究领域肿瘤细胞生物转录调节因子细胞表面分子
蛋白分子量 predicted molecular weight: 63-70kDa
性状 Lyophilized or Liquid
免疫原 KLH conjugated synthetic peptide derived from human RANK C-terminus
亚型 IgG
纯化方法 affinity purified by Protein A
储存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 CD265 is a member of the tumor necrosis factor receptor (TNFR) family. Human and murine CD265 share 81% amino acid identity in their extracellular domains. CD265 is widely expressed, with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. CD265 is also expressed in dendritic cells. RANK and RANK ligand (RANKL) are important regulators of interactions between T cells and dendritic cells. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of CD265. TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for CD265. The biological functions mediated by RANK include activation of NFkappaB and cjun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis. The soluble form of CD265 is able to block TRANCE induced biological activity. The binding of anti-CD265 to cell surface CD265 triggers signal transduction and induces CD265 mediated bioactivity.
Function : Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Subcellular Location : Membrane.
Tissue Specificity : Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.
DISEASE : Defects in TNFRSF11A are the cause of familial expansile osteolysis (FEO) [MIM:174810]. FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. The osteolytic lesions develop usually in the long bones during early adulthood. FEO is often associated with early onset deafness and loss of dentition.
Defects in TNFRSF11A are a cause of Paget disease of bone type 2 (PDB2) [MIM:602080]; also known as familial Paget disease of bone. PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Unlike FEO, however, affected individuals have involvement of the axial skeleton with lesions in the spine, pelvis and skull.
Similarity : Contains 4 TNFR-Cys repeats.
核因子kB受体活化因子 RANK
  核转录因子NF-κB受体抗体(核因子kB受体活化因子)说明书储存温度：
存在于血清、组织培养上清液或腹水中的抗体在-20℃下能够长期储存。低温存放不会损伤抗体活性。抗体的工作液通常储存于4℃中。此温度下，抗体的活性能稳定数月至数年亦不损失。抗体溶液不应反复冻融，因为反复冻融将导致部分抗体失活并产生不需要的蛋白—蛋白凝聚物。抗体的凝聚能导致活性丧失。这是由于抗原结合位点的空间构象被破坏，或由于产生的不溶物被离心或过滤而除去。冷凝蛋白类的抗体不能存放于4℃。因为在4℃下此类抗体会发生沉淀。一些鼠源性IgG3亚类的抗体有此特性。如果抗体在4℃下发生沉淀，就应该存放于室温下的叠氮钠溶液中。
核转录因子NF-κB受体抗体(核因子kB受体活化因子)说明书的分类：
按作用对象，可将其分为抗毒素、KJ抗体、抗病毒抗体和亲细胞抗体（能与细胞结合的免疫球蛋白，如1型变态反应中的lgE反应素抗体，能吸附在靶细胞膜上）；按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类；按抗体的来源，可将其分为天然抗体和免疫抗体。抗体就是免疫球蛋白，是改变了的球蛋白分子。由特异性抗原刺激产生，抗体的产生是由于抗原侵入人体后引起各种免疫细胞相互作用，使淋巴细胞中的B细胞分化增殖而形成浆细胞，浆细胞可产生分泌抗体。
大鼠骨形成蛋白(BMPs)ELISA试剂盒   英文名称：   Rat bone morphogenetic proteins,BMPs ELISA Kit   规格:   96T/48T   人磷酸葡萄糖变位酶(PGM)ELISA Kit，48T/96T
大鼠色素上皮衍生因子(PEDF)ELISA试剂盒   英文名称：   Rat pigment epithelium-derived factor,PEDF ELISA Kit   规格:   96T/48T   人S100B蛋白(S-100B)ELISA Kit，48T/96T
大鼠环孢素A(CsA)ELISA试剂盒   英文名称：   Rat Cyclosporine A,CsA ELISA Kit   规格:   96T/48T   人水通道蛋白4(AQP-4)ELISA Kit，48T/96T
大鼠抗凝血酶受体(ATR)ELISA试剂盒   英文名称：   Rat anti-thrombin receptor,ATR ELISA Kit   规格:   96T/48T   鸭免疫球蛋白E(IgE)ELISA Kit，48T/96T
大鼠水通道蛋白3(AQP-3)ELISA试剂盒   英文名称：   Rat Aquaporin 3,AQP-3 ELISA Kit   规格:   96T/48T   人磷酸化乙酰辅酶A(PaCoA)ELISA Kit，48T/96T
大鼠可溶性P选择素(sP-selectin)ELISA试剂盒   英文名称：   Rat soluble P-selectin,sP-selectin ELISA Kit   规格:   96T/48T   人磷酸化细胞外信号调节激酶(pERK)ELISA Kit，48T/96T
大鼠维生素A(VA)ELISA试剂盒   英文名称：   Rat Vitamin A,VA ELISA Kit   规格:   96T/48T   鸡乙酰乙酸检测(ACAC)ELISA Kit，48T/96T
大鼠基质金属蛋白酶YZ因子3(TIMP-3)ELISA试剂盒   英文名称：   Rat tissue inhibitors of metalloproteinase 3,TIMP-3 ELISA Kit   规格:   96T/48T   人白色念珠菌(C.albicans)ELISA Kit，48T/96T Bovine Serum Albumin – Cohn Fraction V， pH – 7.0   Bovine Serum Albumin – Cohn Fraction V， pH – 7.0
Creatine Kinase Enzyme Mixture （7。5 mg）   Creatine Kinase Enzyme Mixture
甲磺吖庚脲   Tolazamide
DiaEasy Dialyzer (3 ml) MWCO 50 kDa   DiaEasy Dialyzer (3 ml) MWCO 50 kDa
15-R)-17-phenyl trinor Prostaglandin F2α ethyl amide (10 mg)   15(R)-17-phenyl trinor PGF2α ethyl amide|15(R)-Bimatoprost, 15-R)-17-phenyl trinor Prostaglandin F2α ethyl amide, N-ethyl-9α,11α,15R-trihydroxy-17-phenyl-18,19,2-trinor-prosta-5Z,13E-dien-1-amide
-+)-Muscarine -iodide salt) (10 mg)   -+)-Muscarine -iodide salt), 2,5-anhydro-1,4,6-trideoxy-6-(trimethylammonio)-D-ribo-hexitol, iodide
核转录因子NF-κB受体抗体(核因子kB受体活化因子)说明书Alfuzosin -hydrochloride) (100 mg)   Uroxatral|SL 77499-1, Alfuzosin -hydrochloride), N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide, monohydrochloride
10-Pyrene-PC (25 mg)   1-Palmitoyl-2-pyrenedecanoyl Phosphatidylcholine, 10-Pyrene-PC, 1-O-hexadecanoyl-2-O-(1-(1-pyrenyl)decanoyl)-sn-glyceryl-3-phosphorylcholine
α-Linolenoyl Ethanolamide (25 mg)   α-Linolenoyl Ethanolamide, N-(2-hydroxyethyl)-9Z,12Z,15Z-octadecatrienamide
真菌抗生素溶液（100X）（100ML）   Antibiotic-Antimycotic Solution （100X）， Contains 10，000 units of penicillin， 10，000ug streptomycin， and 25ug amphotericin B in a 0.85% saline solution. Effective against bacteria， fungi， and yeasts. Sterile-filtered solution.
L-甲硫氨（500GM）   L-Methionine， CAS# 63-68-3； MW 149.21； ≥99%； USP
核转录因子NF-κB受体抗体(核因子kB受体活化因子)说明书按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类。
IgM抗体是免疫应答中首先分泌的抗体。它们在与抗原结合后启动补体的级联反应。它们还把入侵者相互连接起来，聚成一堆便于巨噬细胞的吞噬；
IgG抗体激活补体，中和多种毒素。IgG持续的时间长，是 WY能在母亲妊娠期穿过胎盘保护胎儿的抗体。他们还从乳腺分泌进入初乳，使新生儿得到保护；
IgA抗体进入身体的黏膜表面，包括呼吸、消化、生殖等管道的黏膜，中和感染因子。还可以通过母乳的初乳把这种抗体输送到新生儿的消化道黏膜中，是在母乳中含量最多，最为重要的一类抗体；
IgE抗体的尾部与嗜碱细胞、肥大细胞的细胞膜结合。当抗体与抗原结合后，嗜碱细胞与肥大细胞释放组织胺一类物质促进炎症的发展。这也是引发速发型过敏反应的抗体；
IgD抗体的作用还不太清楚。它们主要出现在成熟的B淋巴细胞表面上，可能与B细胞的分化有关。（IgD于1995年从人瘤蛋白中发现，分子量为175kD，主要由扁桃体、脾等处浆细胞产生，人血清中IgD浓度为3～40μg/ml,不到血清总Ig的1%，在个体发育中合成较晚。IgD铰链区很长，且对蛋白酶水解敏感，因此IgD半衰期很短，仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段，除了表达SmIgD，抗原刺激后表现为免疫耐受。成熟B细胞活化后或者活化后或者变成记忆B细胞时，SmIgD逐渐消失。

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