抗体 名:p-MEK-1/2 (Ser 218/Ser 222)抗体
规格:200ug
Santa Cruz是美国也是世界上Z大的抗体生产厂家,提供抗体种类多达两万多种,几乎覆盖了目前生命科学研究的各个新领域,其每种抗体又有多个克隆可选择,并有对应蛋白标准品及相关产品,为免疫学研究工作提供了极大的方便。
产品介绍:
p-MEK-1/2 Antibody (Ser 218/Ser 222) is a goat polyclonal IgG provided at 100 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-7995-R
recommended for detection of MEK-1 dually phosphorylated at Ser 218 and Ser 222 and correspondingly phosphorylated MEK-2 of mouse, rat, humand, x origin by WB, IP, IF, IHC(P) and ELISA
blocking peptide, sc-7995 P; also reactive with additional species, including equine, canine, bovine, porcine and avian
agarose conjugate for IP studies, sc-7995 AC, 500 µg/0.25 ml agarose
See 32 citations for p-MEK-1/2 抗体p-MEK-1/2 (Ser 218/Ser 222)抗体基因信息:
A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK (1). A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity (2). MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases (3). MEK-5 appears to specifically phosphorylate ERK5 (4), whereas MEK-6 phosphorylates p38 and p38ß (5,6). MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway (7–9). Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAFor MEKK1) positively regulates the kinase activity.
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p-MEK-1/2 (Ser 218/Ser 222)抗体