ERBB3 Antibodyi-ERBB3 Polyclonal Antibody

英文名称Rabbit ERBB3 Polyclonal Antibody别名ADRA1;ALPHA1BAR应用WB稀释比例WB1:500-1:2000交叉反应Human,Mouse,Rat蛋白分子量148kDaGene ID2065保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.储存液PBS with 0.02% sodium azide, 50% glycerol, pH7.3.纯化方法Affinity purification亚型IgG免疫原Recombinant protein of human ERBB3性状Lyophilized or LiquidSwiss ProtP21860克隆类型Polyclonal Antibody来源Rabbit背景资料This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.