Melanocortin Receptor Antibody Explorer Kit

Melanocortin Receptor Antibody Explorer KitA Screening Package of Melanocortin Receptor Antibodies Economically Priced
Cat #: AK-565
10 Vials

Alomone Labs is pleased to offer the Melanocortin Receptor Antibody Explorer Kit (#AK-565). The Explorer Kit contains melanocortin receptor antibodies, ideal for screening purposes.

• Compounds
• Scientific Background

Product Name	Cat #	Size
Anti-Melanocortin Receptor 1	AMR-020	1 x 50 µl
Anti-Melanocortin Receptor 2 (extracellular)	AMR-022	1 x 50 µl
Anti-Melanocortin Receptor 3 (extracellular)	AMR-023	1 x 50 µl
Anti-Melanocortin Receptor 4 (extracellular)	AMR-024	1 x 50 µl
Anti-Melanocortin Receptor 5	AMR-025	1 x 50 µl

Scientific Background The melanocortin signaling system plays a role in many physiological outcomes such as skin pigmentation, food intake, sexual behavior and more. Melanocortin receptors (MCRs) 1 through 5, belong to the superfamily of G-protein coupled receptors, and mediate the effects of five different peptides: ACTH, α-MSH, β-MSH and γ-MSH. In addition, this system has endogenous antagonists: agouti and AGRP. Agouti inhibits MCR1 and MCR4, while AGRP antagonizes MCR3 and MCR4. These two antagonists, when overexpressed in mice, give rise to obese animals, and in some cases, obese and diabetic subjects.¹
Melanocortin Receptor Antibody Explorer KitReferences 

1. Gantz, I. and Fong, T.M. (2003) Am. J. Physiol. 284, E468.