Cobra Venom Factor (Naja naja kaouthia) A600

For Research Use Only. Not for use in diagnostic procedures.

Cobra Venom Factor (CVF), sometimes referred to as C3b (Cobra), is the non-toxic, complement-activating component of cobra venom. Like naturally occurring human C3b, CVF forms a complex, or convertase, with complement components Factor B and Factor D. This CVFBbD convertase is capable of activating C3 in a wide variety of species via the alternative complement pathway. CVFBbD convertase is Factor H resistant and is therefore not blocked through the activity of Factor I or CR1 and can convert nearly 100% of the C3 to C3 and C5 fragments. Levels of iC3b, C3a, SC5b-9, C5a and the Factor B cleavage product Bb are all extremely high in CVF treated sera.

This product has been used in an experimental setting to deplete complement activity in vitro and in vivo. For more information contact Quidel Technical Support.

Agarwal, Szalai, A. The Arthus Reaction in Rodents: Species Specific Requirement of Complement, J. Immunol 164:463-468, 2000.

Vandenberg, C.W., et al. In Vivo Anti-complementary activities of the cobra venom factros form Naja and Naja haje, J. Immunol. Methods. 13(6):2870294, 1991.

Rajasinghe, H. et al. Key role of the alternative pathway in hyperacute rejection of rat hearts transplanted into fetal sheep, Transplantation. 63(3), 407-426, 1996.

Koymada, N. Bach, F. Transient complement inhibition plus T Cell immuno-suppression induces long term survival of mouse to rat cardiac xenografts, Transplantation. 6(9)1210-1215, 1998.
眼镜蛇毒因子

只供研究使用。不用于诊断过程。

眼镜蛇毒因子（CVF），有时称为C3b（眼镜蛇），是无毒、补体激活眼镜蛇毒成分。喜欢自然发生的人类细胞，CVF形成络合物，或转化，与补体B因子和因子这种cvfbbd转化酶有激活补体C3在各种各样的物种通过补体替代途径。cvfbbd转化是H因子的抗性和因此不通过因子I或CR1活性受阻，可以把近100%的C3 C3和C5片段。IC3B，C3a、C5a和SC5b-9水平，B因子裂解产物BB都在CVF处理血清非常高。

该产品已被用于在体外和体内消耗补体活性的实验装置。更多信息联系Quidel的技术支持。

工具书类

Agarwal，Szalai在啮齿类动物的过敏反应：物种的具体要求补充，J. Immunol 164:463-468，2000。

Vandenberg，C.W.，等。眼镜蛇毒因子在体内形成眼镜和埃及眼镜蛇抗补体活性，J. Immunol。方法.13（6）：2870294, 1991。

拉贾辛哈，H.等人。在大鼠心脏移植到胎羊超急性排斥反应的替代途径的关键作用，移植。63（3），407-426，1996。

Koymada，N. Bach，F.瞬态YZ补体加T细胞免疫YZ诱导长期存活的小鼠到大鼠心脏移植，移植。6（9）1210-1215，1998。