β-Secretase inhibitor b-SECRETASE INHIBITOR

β-Secretase inhibitor
b-SECRETASE INHIBITOR Product Number S 4562 Storage Temperature –20 °C (KTEEISEVN [Statine] VAEF; Lys-Thr-Glu-Glu-Ile-SerGlu-Val-Asn-[Statine]-Val-Ala-Glu-Phe-OH)) Product Description Appearance: White Powder Molecular Formula: C73H118N16O27 Formula Weight: 1651.8 Purity: >97 % by HPLC. A b-secretase inhibitor.1 A key event in Alzheimer’s disease is the sequential proteolytic cleavage of the amyloid protein from the amyloid protein precursor (APP) by b- and g-secretase. b-secretase (BACE), a transmembrane aspartyl protease cleaves the APP to yield the N terminus of the amyloid b peptide. Whereas, g-secretase cleaves the C terminus. Accumulation of the amyloid b peptides results in neuritic plaques in brain parenchy