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Naquotinib( ASP8273) is an orally available, irreversible, third-generation, mutant-selective EGFR inhibitor with IC50 of 8-33 nM toward EGFR mutants, IC50 of 230 nM for WT EGFR.
Naquotinib( ASP8273) is an orally available, irreversible, third-generation, mutant-selective EGFR inhibitor with IC50 of 8-33 nM toward EGFR mutants, IC50 of 230 nM for WT EGFR.
Lapatinib, Inhibitor of Her2/EGFR (IC50=10 nM; mol wt 581; >98%)
AG-18(RG-50810; Tyrphostin A23)YZEGFR，IC50为40 _mu_M。
AG-18(RG-50810; Tyrphostin A23)YZEGFR，IC50为40 μM。
Lapatinib, Inhibitor of Her2/EGFR (IC50=10 nM; mol wt 581; >98%)
Dacomitinib(PF299804) is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.
Naquotinib is a mutant-selective irreversible EGFR inhibitor with IC50 of 70 nM for NCI-H1650 cell growth,inhibits growth of non-small cell lung cancer (NSCLC) cells with EGFR activating and T790M resistance mutations.
Canertinib is an orally bioavailable irreversible Pan-erbB tyrosine kinase inhibitor, targeting EGFR with IC50 of 0.8, 19 and 7 nM for EGFR, HER-2 and ErbB-4, respectively.
PD168393 is an potent, cell-permeable, irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773, inactive against insulin, PDGFR, FGFR and PKC.
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively.
CO-1686 hydrobromide is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M (IC50=21 nM).
CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370_addition_/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.
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