MLN8237(Alisertib)4-[[9-氯-7-(2-氟-6-甲氧基苯基)-5H-嘧啶并[5,4-D][2]苯并氮杂卓-2-基]氨基]-2-甲氧基苯甲酸

ID：T2241

PURITY：97%+

Formula：C27H20ClFN4O4

MolWt：518.9235032

Appearance：黄色粉末

Solubility：G4Soluble in DMSO

Bioactivity：Alisertib is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers.

Status：

Pathways：Cell Cycle/Checkpoint

Target：Aurora Kinase inhibitor

Receptor：Aurora A, Aurora B