Lapatinib ditosylate二甲苯磺酸拉帕替尼

ID：T0078L

PURITY：0.98

Formula：C29H26ClFN4O4S.2(C7H8O3S)

MolWt：925.48

Appearance：无色或淡黄色结晶

Solubility：G4Soluble in DMSO

Bioactivity：Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug Capecitabine. Lapatinib is human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1) tyrosine kinases inhibitor. It binds to the intracellular phosphorylation domain to prevent receptor autophosphorylation upon ligand binding.

Status：USP,INN

Pathways：Tyrosine Kinase/Adaptors; JAK/STAT Signaling

Target：EGFR inhibitor; HER2 inhibitor

Receptor：EGFR, ErbB2