PML/RARA Dual Color Single Fusion Probe

The PML/RARA Dual Color Single Fusion Probe is intended to detect the t(15;17)(q22;q21.1) reciprocal translocation involving the PML and RARA gene regions.The vast majority of cases of acute promyelocytic leukemia (APL) have a t(15;17)(q22;q21.1) translocation which fuses the promyelocytic leukemia gene (PML) on chromosome 15q22-q24 to the retinoic acid receptor alpha gene. The PML/RARA fusion is associated with a good response to all-trans retinoic acid therapy.This Probe was used in a study of 260 acute myeloid leukemia patients and detected 11 positive samples. In the same study, conventional banding analysis resulted in only 7 positive results due to cytogenetic failure and one case of a cryptic translocation. Know more at: http://www.creative-bioarray.com/PML-RARA-Dual-Color-Single-Fusion-Probe-FHPC-088-item-4729.htm