IGH/MYEOV Translocation, Dual Fusion Probe

The most common translocation in Multiple Myeloma is the t(11;14)(q13;q32) which accounts for 15-20% of cases that were identified by FISH. These translocations lead to overexpression of Cyclin D1 in about 25% of cases. The breakpoints in Multiple Myeloma cases are dispersed within a 360Kb region between CCND1 and MYEOV genes. MYEOV is a putative oncogene and it's thought to be activated in the translocation by it becoming closely associated with IGH enhancers, which results in a poor prognosis for the patient. Know more at: http://www.creative-bioarray.com/IGH-MYEOV-Translocation,-Dual-Fusion-Probe-FHPC-071-item-4712.htm