突触可塑性PCR基因芯片 Synaptic Plasticity PCR Array

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Synaptic Plasticity PCR Array

突触可塑性PCR基因芯片
 

Product	Species	Technology	Cat. No.
Synaptic Plasticity PCR Array	Human	Gene Expression	PAHS-126Z
Synaptic Plasticity PCR Array	Mouse	Gene Expression	PAMM-126Z
Synaptic Plasticity PCR Array	Rat	Gene Expression	PARN-126Z

  
   Synaptic Plasticity RT² Profiler™ PCR Array profiles the expression of 84 key genes central to synaptic alterations during learning and memory. The brain recalls immediate events via short-term memories; however, it must consolidate these events into long-term memory for later recall. Memory consolidation requires synaptic plasticity characterized by physical changes to, and gene expression changes in, neuronal synapses. Synaptic plasticity studies have discovered immediate-early genes (IEGs) that alter expression immediately after neuronal events. IEGs mediate long-term potentiation (LTP), a process that enhances synaptic connections and consolidates memories. However, as not all events become long-term memories, the opposite synaptic remodeling response, long-term depression (LTD), also plays a central role in synaptic plasticity. Gene expression changes associated with LTD yield physical changes in the neuronal synapse that recycle receptors and either enhance or inhibit synaptic connections. This array includes IEGs and other genes important for LTP and LTD, as well as key neuronal receptor genes and genes important for synapse remodeling. Using real-time PCR, you can easily and reliably analyze the expression of a focused panel of genes involved in synaptic plasticity, LTP and LTD with this array.

    突触可塑性PCR基因芯片可以同时检测学习和记忆过程中参与突触改变的84个关键基因的表达。对于回忆，大脑可以有两种方式记录以往事件：短期记忆和长期记忆。其中长期记忆需要突触物理性的改变，并伴有神经突触相关基因表达的变化。突触可塑性的研究已经发现神经元的活动变化后，即早基因(IEGs)的表达立即改变。IEGs介导的长时程增强（LTP）可以增强突触连接并巩固记忆。然而并非所有事件都成为长期记忆，相反的突触重塑反应（长时程YZ，LTD），在突触可塑性也起到了核心作用。LTD相关基因的表达变化可以改变神经元突触受体的循环，从而增强或YZ突触连接。该芯片包含IEGs，其他参与LTP和LTD的重要基因，以及参与突触重塑的关键受体基因等。利用实时定量PCR，研究者可以方便并且可信地对参与突触可塑性的相关基因进行同时检测。
Immediate-Early Response Genes (IEGs):ARC, BDNF, CEBPB, CEBPD, CREB1, CREM, EGR1, EGR2, EGR3, EGR4, FOS, HOMER1, JUN, JUNB, KLF10, MMP9 (Gelatinase B), NFKB1, NFKBIB (TRIP9), NGF, NPTX2, NR4A1, NTF3, PCDH8, PIM1, PLAT (tPA), RELA, RGS2, RHEB, SRF, TNF.
Late Response Genes:INHBA, SYNPO.
Long Term Potentiation (LTP):ADCY1, ADCY8, BDNF, CAMK2A, CAMK2G, CDH2 (N-cadherin), CNR1, GABRA5, GNAI1, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, MAPK1, MMP9 (Gelatinase B), NTF4, NTRK2, PLCG1, PPP1CA, PPP1CC, PPP3CA, PRKCA, PRKCG, RAB3A, YWHAQ (14-3-3).
Long Term Depression (LTD):GNAI1, GRIA1, GRIA2, GRIA3, GRIA4, GRIP1, GRM1, GRM2, IGF1, MAPK1, NOS1, NGFR, PICK1, PLAT (tPA), PPP1CA, PPP1CC, PPP1R14A (CPI-17), PPP2CA, PPP3CA, PRKCA, PRKG1.
Cell Adhesion:ADAM10, CDH2 (N-cadherin), GRIN2A, GRIN2B, NCAM1, PCDH8, PPP2CA, RELN, TNF.
Extracellular Matrix & Proteolytic Processing:ADAM10, MMP9 (Gelatinase B), PLAT (tPA), RELN, TIMP1.
CREB Cofactors:AKT1, CAMK2G, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, MAPK1 (ERK2), PPP1CA, PPP1CC.
Neuronal Receptors:EPHB2, GABRA5, GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8, NTRK2.
Postsynaptic Density: ADAM10, ARC, DLG4 (PSD95), GRIA1, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRM1, GRM3, HOMER1, PICK1, SYNPO.
Others:KIF17, SIRT1.