蛋白磷酸化酶PCR基因芯片Protein Phosphatases PCR Array

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Protein Phosphatases PCR Array

蛋白磷酸化酶PCR基因芯片
 

Product	Species	Technology	Cat. No.
Protein Phosphatases PCR Array	Human	Gene Expression	PAHS-045Z
Protein Phosphatases PCR Array	Mouse	Gene Expression	PAMM-045Z
Protein Phosphatases PCR Array	Rat	Gene Expression	PARN-045Z

Protein Phosphatases RT² Profiler™ PCR Array profiles the gene expression of the 84 most important and well-studied phosphatases in the mammalian genome. By reversing the phosphorylation of key regulatory proteins mediated by protein kinases, phosphatases serve as a very important complement to kinases and attenuate activated signal transduction pathways. The gene classes on this array include both receptor and non-receptor tyrosine phosphatases, catalytic subunits of the three major protein phosphatase gene families, the dual specificity phosphatases, as well as cell cycle regulatory and other protein phosphatases. Alterations in phosphatase activity, including those caused by changes in gene expression, have been implicated in central nervous system and metabolic disorders, infectious diseases, and cancer. Using real-time PCR, you can easily and reliably analyze the expression of a focused panel of phosphatase genes with this array.
蛋白磷酸化酶PCR基因芯片可以同时检测与蛋白磷酸化酶相关的84个重要基因的表达。蛋白磷酸化酶可以反转关键蛋白被蛋白激酶（kinase）所磷酸化的特定位点，从而广泛的参与蛋白激酶对信号转导的调控。该芯片同时包括受体型和非受体型的酪氨酸磷酸化酶，三个主要蛋白磷酸化酶基因家族的催化亚基，双特异性磷酸化酶，细胞周期调控相关及其他蛋白磷酸化酶。磷酸化酶活性的改变，包括基因表达的变化会引起神经系统和代谢系统疾病，感染性疾病，且与癌症有关。利用实时定量PCR，研究者可以方便并且可信地对磷酸化酶通路相关基因进行同时检测。
Protein Tyrosine Phosphatases:
Receptor Type:PTPRA, PTPRB, PTPRC, PTPRD, PTPRE, PTPRF, PTPRG, PTPRH, PTPRJ, PTPRK, PTPRM, PTPRN, PTPRN2, PTPRO, PTPRR, PTPRS, PTPRT, PTPRU, PTPRZ1.
Non-Receptor Type:PTPN1, PTPN11, PTPN12, PTPN13, PTPN14, PTPN2, PTPN21, PTPN22, PTPN23, PTPN3, PTPN4, PTPN5, PTPN6, PTPN7, PTPN9.
Others:PTP4A1, PTP4A2, PTP4A3, PTPLA.
Protein Phosphatases, Catalytic Subunits:PPM1A, PPM1B, PPM1D, PPM1F, PPM1G, PDP1, PPP1CA, PPP1CB, PPP2CA, PPP2CB, PPP3CA, PPP3CB, PPP3CC, PPP4C, PPP5C.
Dual Specificity Phosphatases:DUSP1, DUSP10, DUSP12, DUSP14, DUSP16, DUSP22, DUSP23, DUSP26, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9.
Cell Cycle Phosphatase:CDC14A, CDC14B, CDC25A, CDC25B, CDC25C, CDKN3.
Others:ACP1, ACP2, ILKAP, PHLPP1, PPEF1, PTEN, SSH1, SSU72, TENC1, TPTE.