Dolutegravir, C20H19F2N3O5

分子式：C20H19F2N3O5；分子量：419.38；外观：White to Pale Yellow Solid；溶解性：DMSO (Slightly, Sonicated, Heated), Methanol (Slightly, Heated)；别名：(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide; GSK 1349572; S/GSK1349572；熔点：188-192°C；应用：Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.；类别：Anti-virals, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates