简介： 货 号：LC1-P-7050 名 称：2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-A]吡啶-3-基)亚甲基]甲肼基盐酸盐 别 名：PIK-75 Hydrochloride Salt C A S ：372196-77-5 分子量：488.74 分子式：C16H14BrN5O4S•HCl 纯 度：HPLC/TLC:>99% 说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A. 文 献：PIK-75-mediated anti-inflammatory effects are associated with dramatic inhibition of AKT phosphorylation, IKK activation and NF-κB transcription. Dagia, N.M., et al. "A Preferential p110α/γ PI3K Inhibitor Attenuates Experimental Inflammation by Suppressing the Production of Proinflammatory Mediators in NF-κB Dependent Manner." Am. J. Physiol. Cell Physiol. 298: C929-C941 (2010).PIK-75 completely inhibited adipocyte differentiation. Kim, J.E., et al. "Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation." Biochem. Biophys. Res. Commun. 379: 830-834 (2009).Insulin-like growth factor-1 (IGF-1) potentiates PAR-1-mediated platelet aggregation. PIK-75 and PI-103 completely inhibited this potentiation, indicating PI3Kα; is essential for the enhancement by IGF-1 of platelet responses. Hers, I. "Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway." Blood 110: 4243-4252 (2007).In addition to the p110α isotype of PI3K , p110β and p110δ can also play a role in insulin signalling. Chaussade, C., et al. "Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling." Biochem. J. 404: 449-458 (2007).
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