6-[(氨基羰基)(2,6-二氟苯基)氨基]-2-(2,4-二氟苯基)-3-吡啶甲酰胺_详细资料

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CAS号： 745833-23-2 供应商：上海经科化学科技有限公司数量：期货2-3周英文名： VX-702 Free Base 保质期：＞1年保存条件：见说明书规格： 10mg

供应商：上海经科化学科技有限公司

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本试剂(6-[(氨基羰基)(2,6-二氟苯基)氨基]-2-(2,4-二氟苯基)-3-吡啶甲酰胺)
仅供科研实验使用,不得用于其他用途！

简介：
货号：LC1-V-9366
名称：6-[(氨基羰基)(2,6-二氟苯基)氨基]-2-(2,4-二氟苯基)-3-吡啶甲酰胺
别名：VX-702 Free Base
C A S ：745833-23-2
分子量：404.32
分子式：C19H12F4N4O2
纯度：HPLC/TLC:>99%
说明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.
文献：VX-702 is a second-generation, orally active mitogen-activated protein kinase (MAPK) p38 inhibitor. It is being tested for the potential treatment of inflammation, rheumatoid arthritis and cardiovascular diseases. Ding, C. "Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome." Curr. Opin. Investig. Drugs 7: 1020-1025 (2006).p38 MAPK increases thromboxane levels by activating phospholipase A2, thus catalyzing the formation of arachidonic acid. VX-702 inhibited activation of p38 MAPK by thrombin, SFLLRN, AYPGKF and U46619 in platelets. Kuliopulos, A., et al. "Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation." Thromb. Haemost. 92: 1387-1393 (2004).VX-702 showed modest clinical efficacy and transient suppression of biomarkers of inflammation in patients with rheumatoid arthritis. Damjanov, N., et al. "Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies." Arthritis Rheum. 60: 1232-1241 (2009).

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6-[(氨基羰基)(2,6-二氟苯基)氨基]-2-(2,4-二氟苯基)-3-吡啶甲酰胺

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