42-(二甲基亚膦酰)雷帕霉素;雷帕霉素衍生物;药雷帕霉素_详细资料

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CAS号： 572924-54-0 供应商：上海经科化学科技有限公司数量：期货2-3周英文名： Ridaforolimus 保质期：＞1年保存条件：见说明书规格： 5mg

供应商：上海经科化学科技有限公司

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本试剂(42-(二甲基亚膦酰)雷帕霉素;雷帕霉素衍生物;药雷帕霉素)
仅供科研实验使用,不得用于其他用途！

简介：
货号：LC1-R-7040
名称：42-(二甲基亚膦酰)雷帕霉素;雷帕霉素衍生物;药雷帕霉素
别名：Ridaforolimus
C A S ：572924-54-0
分子量：990.21
分子式：C53H84NO14P
纯度：HPLC/TLC:>99%
说明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A
文献：Ridaforolimus (the name has been changed from "deforolimus") is an immunosuppressant and a novel small-molecule inhibitor of the protein mammalian target of rapamycin (mTOR). Ridaforolimus inhibits cancer cell growth, cell division, metabolism, and angiogenesis by blocking mTOR. Mahalingam, D., et al. "Targeting the mTOR pathway using deforolimus in cancer therapy." Future Oncol. 5: 291-303 (2009).Ridaforolimus had an antitumor activity in >85% of patients with advanced solid tumors. Rivera, V.M., et al. "Pharmacodynamic study of skin biopsy specimens in patients (pts) with refractory or advanced malignancies following administration of AP23573, an mTOR inhibitor." J. Clin. Oncol. 23: 3033 (2005).Ridaforolimus has low toxicity profiles and promising clinical efficacy in patients with advanced sarcomas. Chawla, S.P., et al. "Updated results of a phase II trial of AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas." J. Clin. Oncol. 24: 9505 (2006).The level of phosphorylated S6 ribosomal protein expression was a marker of early tumor response to ridaforolimus. Iwenofu, O.H., et al. "Phospho-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted mTOR therapy." Mod. Pathol. 21: 231-237 (2008).MEK inhibitors in combination with the mTOR inhibitor, rapamycin or its analogue ridaforolimus, exhibited synergism in human lung cancer cell lines by inhibiting proliferation rather than promoting cell death. Legrier, M.E., et al. "Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression." Cancer Res. 67: 11300-11308 (2007).

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42-(二甲基亚膦酰)雷帕霉素;雷帕霉素衍生物;药雷帕霉素

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