简介: 货 号:LC1-I-6800 名 称:钙离子霉素;罗红霉素钙盐;罗红霉素(游离酸) 别 名:Ionomycin Calcium Salt C A S :56092-82-1 分子量:747.07 分子式:C41H70O9•Ca 纯 度:HPLC/TLC:>99% 说 明:Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A. 文 献:Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption. Liu, C. and Hermann T.E. "Characterization of ionomycin as a calcium ionophore." J. Biol. Chem. 253: 5892-5894 (1978). Kauffman, R.F., et al. "Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria." J. Biol. Chem. 255: 2735-2739 (1980).Ionomycin induces apoptosis in immature B cell lines, for example, in Burkitt lymphoma cells, and in cultured embryonic rat cortical neurons. More mature B cell lines do not undergo apoptosis, but are arrested in the G1 phase of the cell cycle. Takei, N. and Endo, Y. "Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons." Brain Res. 652: 65-70 (1994). Aagaard-Tillery, K.M., et al. "Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis." J. Immunol. 155: 3297-3307 (1995).