3-[1-[3-(二甲基氨基)丙基]-5-甲氧基-1H-吲哚-3-基]-4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮_详细资料

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CAS号： 133053-19-7 供应商：上海经科化学科技有限公司数量：期货2-3周英文名： GO 6983 Free Base 保质期：＞1年保存条件：见说明书规格： 1mg

供应商：上海经科化学科技有限公司

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本试剂(3-[1-[3-(二甲基氨基)丙基]-5-甲氧基-1H-吲哚-3-基]-4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮)
仅供科研实验使用,不得用于其他用途！

简介：
货号：LC1-G-7700
名称：3-[1-[3-(二甲基氨基)丙基]-5-甲氧基-1H-吲哚-3-基]-4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮
别名：GO 6983 Free Base
C A S ：133053-19-7
分子量：442.51
分子式：C26H26N4O3
纯度：HPLC/TLC:>99%
说明：
文献：Gö 6983 is a potent, cell-permeable, ATP-competitive inhibitor of protein kinase C (PKC). It inhibited PKC isozymes with IC50 values of 7 nM for PKC[alpha] and PKC[beta]; 6 nM for PKC[gamma]; 10 nM for PKC[delta]; and 60 nM for PKC[zeta]. Gö 6983 weakly inhibited PKC[mu] with an IC50 of 20 µM. Gschwendt M., et al. "Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes." FEBS Lett. 392: 77-80 (1996).PKC inhibitors RO 31-8220 and Gö 6983 increased Akt phosphorylation and enhanced epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets. Kim S.Y., et al. "PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation." BMB Rep. 44: 140-145 (2011).The aggregated form of Hsp27 in cultured cells became dissociated as a result of phosphorylation with various types of stress. Phorbol ester (PMA)-induced dissociation of Hsp27 was completely suppressed by staurosporine, Go 6983 and bisindolylmaleimide I, inhibitors of protein kinase C and partially suppressed by SB 203580 or PD 169316, inhibitors of p38 MAP kinase but not by PD 98059 and Uo 126, inhibitors of MAP kinase kinase (MEK). Kato K., et al. "Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27." Cell Stress Chaperones 6: 16-20 (2001).

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3-[1-[3-(二甲基氨基)丙基]-5-甲氧基-1H-吲哚-3-基]-4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮

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