R-Phycoerytrhin LOX-1 antibody conjugate (LOX19-22)

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a 31kD type II transmembrane protein belonging to the C-type lectin family. It is expressed primarily on endothelial cells and functions as a scavenger receptor that binds to a range of ligands including oxidized low density lipoprotein (LDL), a major component of atherosclerotic plaques.A soluble form of LOX-1 (sLOX-1) has been identified, which is produced by proteolytic cleavage of LOX-1 from the cell surface and released into the circulation under pathological conditions. Reports show that circulating sLOX-1 levels are dramatically elevated in patients with inflammatory and atherosclerotic conditions and in acute coronary syndrome (ACS), suggesting that sLOX-1 may be a marker of atherosclerotic plaque instability and may be a specific and sensitive biomarker for ACS.