Recombinant Human HIV-1 Tat Interactive Protein 2

Synonyms    TIP30, CC3, SDR44U1, HTATIP2, EC=1.1.1.-, HIV-1 TAT-interactive protein 2, FLJ26963.

Introduction    HTATIP2 is part of the short-chain dehydrogenases/reductases (SDR) family which acts as a tumor suppressor in metabolic suppression, inhibition of angiogenesis and induces the expression of apoptosis related genes Bad and Siva. HTATIP2 cooperates with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II). Defects in HTATIP2 are related with hepatocellular carcinomas and apoptotic resistant tumor cells, implicating a probable use for HTATIP2 in antitumor therapy.

Recombinant Human HIV-1 Tat Interactive Protein 2Description    HTATIP2 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 262 amino acids (1-242 a.a.) and having a molecular mass of 29.3 kDa. The HTATIP2 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Source    Escherichia Coli.

Physical Appearance    Sterile filtered colorless solution.

Formulation    HTATIP2 Human solution containing 20mM Trsi pH-8, 0.1M NaCl& 20% glycerol.

Recombinant Human HIV-1 Tat Interactive Protein 2Stability    HTATIP2 Human although stable at 4℃ for 1 week, should be stored desiccated below -18℃.

Please prevent freeze thaw cycles.

Purity    Greater than 95.0% as determined by SDS-PAGE.

Amino acid sequence    MGSSHHHHHH SSGLVPRGSH MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWARGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP.