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产品中文名称: 常春藤苷H 128730-82-5使用说明书
中文别名: 灰毡毛忍冬次皂苷甲
英文名: Kalopanaxsaponin H
英文别名: Macranthoside A
CAS登录号: 128730-82-5
分子式: C47H76O17
分子量: 912
分子结构:
外观: 白色晶体
规格: 5 mg/支
纯度: HPLC≥98%
用途: 用于含量测定/鉴定/药理实验等。
提取来源: 毛莨科植物白头翁Pulsatilla chinensis (Bunge) Regel.
溶解性: 可溶于甲醇、乙腈、乙醇等溶剂,不溶于石油醚。
药理药效: 抗肿瘤活性。
贮存条件: 4℃冷藏、密封、避光
有效期: 2年
产品名称 | 常春藤苷H 128730-82-5使用说明书
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英文名称 | Macranthoside A
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包装 | 可根据客户要求订制 |
注意事项:
常春藤苷H 128730-82-5使用说明书纯度高,检测/鉴别精确,稳定性强,为了防止产品含量降低,不宜暴露在空气中,应防潮、避光和抗氧化包装,保存应以提高物质稳定性为原则,尽可能在干燥、低温条件下储藏(液体或易潮解物质分装在熔封的玻璃安瓶内)。
规格:规格包装齐全可根据要求定制包装。
用途:产品供科研实验使用,详情可参照产品说明书。
运输:快递免费送货上门,全国各地现货供应。
常春藤苷H 128730-82-5使用说明书不能直接用于人体,出库的产品全部经过严格的检测,保证质量。标准品/对照品一般用于鉴别、检查和含量 (或效价)测定。对于鉴别来说,只要确认未混淆标准物质 即可,而检查和含量测定则不同,大部分检查项目和含量测定项目均有明确的标准。这就要求在进行检验时要控制实验误差,在进行标准物质称量时未严格按照药典等标准要求进行。
大鼠促甲状腺素(TSH)elisa分析检测试剂盒 用于测定血清、血浆、组织和相关液体样本中的含量或者活性,规格96T/48T,存储条件:2-8℃,有效期:6个月 英文缩写: TSH ELISA Kit 常用试剂名称: 大鼠促甲状腺素(TSH)elisa检测试剂盒 规格: 48T/96T。
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大鼠雌激素硫酸转移酶(SULT1E1)elisa分析检测试剂盒 用于测定血清、血浆、组织和相关液体样本中的含量或者活性,规格96T/48T,存储条件:2-8℃,有效期:6个月 英文缩写: SULT1E1 ELISA Kit 常用试剂名称: 大鼠雌激素硫酸转移酶(SULT1E1)elisa检测试剂盒 规格: 48T/96T。
Interacts with AGAP2 (isoform 2/PIKE-A); the interaction occurs in the presence of guanine nucleotides. Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell-cycle progression. Interacts with MAP3K5 and TRAF6. Interacts with BAD, PPP2R5B, STK3 and STK4. Interacts (via PH domain) with SIRT1. Interacts with SRPK2 in a phosphorylation-dependent manner. Interacts with RAF1. Interacts with TRIM13; the interaction ubiquitinates AKT1 leading to its proteasomal degradation. Interacts with TNK2 and CLK2. Interacts (via the C-terminus) with THEM4 (via its C-terminus). Interacts with and phosphorylated by PDPK1.
Subcellular Location : Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.
Tissue Specificity : Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
Post-translational modifications : O-GlcNAcylation at Thr-305 and Thr-312 inhibits activating phosphorylation at Thr-308 via disrupting the interaction between AKT1 and PDPK1. O-GlcNAcylation at Ser-473 also probably interferes with phosphorylation at this site.
Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Activated TNK2 常春藤苷H 128730-82-5使用说明书phosphorylates it on Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. This phosphorylated form localizes to the cell membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308 and Ser-473 leading to its activation. Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1.