Beta Amyloid 42 Polyclonal Antibody, Purified IgG Fraction (SIGNET)_详细资料

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靶点：来电咨询浓度： 1mg/1ml 应用范围：科研使用宿主： Goat，Rabbit，Mouse 适应物种：人，大鼠，小鼠，兔标记物：见说明书克隆性：多克隆保存条件： -20℃保存形态：液态/粉状

Beta Amyloid 42 Polyclonal Antibody, Purified IgG Fraction (SIGNET)详细信息：

Description Purified IgG Fraction of Polyclonal Antibody against Beta Amyolid (Aβ) 42
(Formerly Signet Catalog Nos.: 9134-02, 9134-05, 9134-10)

Intended Use **Research Use Only (RUO)**

This product is sold for laboratory research use only, not for human or in-vivo use.

Form Purified Antibody IgG Fraction (in PBS; no preservatives or carrier proteins)

Host Rabbit

[Ab] Beta Amyloid 42 Polyclonal Antibody, Purified IgG Fraction (SIGNET)0.5 mg/mL

Specificity Covance’s rabbit anti beta amyloid (Aβ) 42 antibody is specific for the C-terminus of Aβ 42. The rabbit anti Aβ 42 reacts extremely well with the 42 isoform. The rabbit anti Aβ 42 antibody does not cross-react with Aβ 40 or APP. Altered levels of Aβ isoforms, specifically the Aβ 40 and Aβ 42 have been shown in the brain tissues and CSF of Alzheimer’s Disease patients.

This antibody was generated against a peptide conjugated to keyhole limpet hemocyanin.

Uses This antibody is effective in immunohistochemistry (IHC).

Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition.

IHC:
Pretreatment: The epitope must be re-exposed in fixed tissue by pretreatment of tissue using formic acid (70%) for 10-30 minutes at room temperature.

Storage Do not store antibody diluted below 50 ug/mL in the absence of protein (i.e.: add 2% bovine serum albumin). The antibody is best stored undiluted at -20°C to -70°C.

References Beta Amyloid 42 Polyclonal Antibody, Purified IgG Fraction (SIGNET)Costantini, C, et al. A TrkA to p75NTR molecular switch activates amyloid beta-peptide generation during aging. Biochem. J. June 20, 2005.

Van Groen T, et al. Transformation of diffuse beta-Amyloid precursor protein and beta-Amyloid deposits to placques in the thalamus after transient occlusion of the middle cerebral artery in rats. Stroke 36(7):1551-6, 2005.

Mehta PD, et al. Amyloid beta protein 40 and 42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. Neurosci. Lett. 304(1-2):102-6, 2001.

Schupf N, et al. Elevated plasma amyloid beta-peptide 42 and onset of dementia in adults with Down syndrome. Neurosci Lett. 301(3):199-203, 2001.

Mehta PD, et al. Plasma and cerebrospinal fluid levels of amyloid beta proteins 40 and 42 in Alzheimer disease. Arch. Neurol. 57(1):100-5, 2000.

Tapiola T, et al. Relationship between apoE genotype and CSF beta-amyloid (42) and tau in patients with probable and definite Alzheimers disease. Neurobiol Aging. 21(5):735-40, 2000.

Emmerling MR, et al. Traumatic brain injury elevates the Alzheimers amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury. Ann NY Acad Sci. 903:118-22, 2000.

Potempska A, et al. Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides. Amyloid 6(1):14-21, 1999.

Mayeux R, et al. Plasma amyloid beta-peptide 42 and incipient Alzheimers disease.Ann Neurol. 46(3):412-6, 1999.

Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval.

Beta Amyloid 42 Polyclonal Antibody, Purified IgG Fraction (SIGNET)

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Beta Amyloid 42 Polyclonal Antibody, Purified IgG Fraction (SIGNET)

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Description		Purified IgG Fraction of Polyclonal Antibody against Beta Amyolid (Aβ) 42 (Formerly Signet Catalog Nos.: 9134-02, 9134-05, 9134-10)
Intended Use		Research Use Only (RUO) This product is sold for laboratory research use only, not for human or in-vivo use.
Form		Purified Antibody IgG Fraction (in PBS; no preservatives or carrier proteins)
Host		Rabbit
[Ab]		Beta Amyloid 42 Polyclonal Antibody, Purified IgG Fraction (SIGNET)0.5 mg/mL
Specificity		Covance’s rabbit anti beta amyloid (Aβ) 42 antibody is specific for the C-terminus of Aβ 42. The rabbit anti Aβ 42 reacts extremely well with the 42 isoform. The rabbit anti Aβ 42 antibody does not cross-react with Aβ 40 or APP. Altered levels of Aβ isoforms, specifically the Aβ 40 and Aβ 42 have been shown in the brain tissues and CSF of Alzheimer’s Disease patients. This antibody was generated against a peptide conjugated to keyhole limpet hemocyanin.
Uses		This antibody is effective in immunohistochemistry (IHC).
Suggested Working Dilution		The optimal working dilution should be determined for each specific assay condition. IHC: Pretreatment: The epitope must be re-exposed in fixed tissue by pretreatment of tissue using formic acid (70%) for 10-30 minutes at room temperature.
Storage		Do not store antibody diluted below 50 ug/mL in the absence of protein (i.e.: add 2% bovine serum albumin). The antibody is best stored undiluted at -20°C to -70°C.
References		Beta Amyloid 42 Polyclonal Antibody, Purified IgG Fraction (SIGNET)Costantini, C, et al. A TrkA to p75NTR molecular switch activates amyloid beta-peptide generation during aging. Biochem. J. June 20, 2005. Van Groen T, et al. Transformation of diffuse beta-Amyloid precursor protein and beta-Amyloid deposits to placques in the thalamus after transient occlusion of the middle cerebral artery in rats. Stroke 36(7):1551-6, 2005. Mehta PD, et al. Amyloid beta protein 40 and 42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. Neurosci. Lett. 304(1-2):102-6, 2001. Schupf N, et al. Elevated plasma amyloid beta-peptide 42 and onset of dementia in adults with Down syndrome. Neurosci Lett. 301(3):199-203, 2001. Mehta PD, et al. Plasma and cerebrospinal fluid levels of amyloid beta proteins 40 and 42 in Alzheimer disease. Arch. Neurol. 57(1):100-5, 2000. Tapiola T, et al. Relationship between apoE genotype and CSF beta-amyloid (42) and tau in patients with probable and definite Alzheimers disease. Neurobiol Aging. 21(5):735-40, 2000. Emmerling MR, et al. Traumatic brain injury elevates the Alzheimers amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury. Ann NY Acad Sci. 903:118-22, 2000. Potempska A, et al. Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides. Amyloid 6(1):14-21, 1999. Mayeux R, et al. Plasma amyloid beta-peptide 42 and incipient Alzheimers disease.Ann Neurol. 46(3):412-6, 1999.
Warranty/Conditions		Covance products may not be resold or modified for resale without prior written approval.