Beta Amyloid 42 Polyclonal Antibody, Biotin Labeled IgG Fraction (SIGNET)_详细资料

产品信息

靶点：来电咨询浓度： 1mg/1ml 应用范围：科研使用宿主： Goat，Rabbit，Mouse 适应物种：人，大鼠，小鼠，兔标记物：见说明书克隆性：多克隆保存条件： -20℃保存形态：液态/粉状

Beta Amyloid 42 Polyclonal Antibody, Biotin Labeled IgG Fraction (SIGNET)详细信息：

Description Biotinylated IgG Fraction Polyclonal Antibody against Beta Amyloid (Aβ) 42
(Formerly Signet Catalog Nos.: 9135-02, 9135-05, 9135-10)

Intended Use **Research Use Only (RUO)**

This product is sold for laboratory research use only, not for human or in-vivo use.

Form Biotin Labeled IgG Fraction (Stored in PBS + 50% Glycerol; no preservatives or carrier proteins)

Host Beta Amyloid 42 Polyclonal Antibody, Biotin Labeled IgG Fraction (SIGNET)Rabbit

Specificity Covance’s rabbit anti beta amyloid (Aβ) 42 antibody is specific for the C-terminus of Aβ 42. The rabbit anti Aβ 42 reacts extremely well with the 42 isoform. The rabbit anti Aβ 42 antibody does not cross-react with Aβ 40 or APP. Altered levels of Aβ isoforms, specifically the Aβ 40 and Aβ 42 have been shown in the brain tissues and CSF of Alzheimer’s Disease patients.

This antibody was generated against a peptide conjugated to keyhole limpet hemocyanin.

Uses This antibody is effective in immunohistochemistry (IHC).

Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition.

IHC:
Pretreatment: The epitope must be re-exposed in fixed tissue by pretreatment of tissue using formic acid (70%) for 10-30 minutes at room temperature

Storage Do not store antibody diluted below 50 ug/mL in the absence of protein (i.e.: add 2% bovine serum albumin). The antibody is best stored undiluted at -20°C to -70°C.

References Mehta PD, et al. Amyloid beta protein 40 and 42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. Neurosci Lett 304(1-2):102-6, 2001.

Schupf N, et al. Elevated plasma amyloid beta-peptide 42 and onset of dementia in adults with Down syndrome. Neurosci Lett 301(3):199-203, 2001.

Mehta PD, et al. Plasma and cerebrospinal fluid levels of amyloid beta proteins 40 and 42 in Alzheimer disease. Arch Neurol 57(1):100-5, 2000.

Beta Amyloid 42 Polyclonal Antibody, Biotin Labeled IgG Fraction (SIGNET)Tapiola T, et al. Relationship between apoE genotype and CSF beta-amyloid (42) and tau in patients with probable and definite Alzheimers disease. Neurobiol Aging 21(5):735-40, 2000.

Emmerling MR, et al. Traumatic brain injury elevates the Alzheimers amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury. Ann NY Acad Sci 903:118-22, 2000.

Potempska A, et al. Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides. Amyloid 6(1):14-21, 1999.

Mayeux R, et al. Plasma amyloid beta-peptide 42 and incipient Alzheimers disease.Ann Neurol. 46(3):412-6, 1999.

Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval.

Beta Amyloid 42 Polyclonal Antibody, Biotin Labeled IgG Fraction (SIGNET)

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Beta Amyloid 42 Polyclonal Antibody, Biotin Labeled IgG Fraction (SIGNET)

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Description		Biotinylated IgG Fraction Polyclonal Antibody against Beta Amyloid (Aβ) 42 (Formerly Signet Catalog Nos.: 9135-02, 9135-05, 9135-10)
Intended Use		Research Use Only (RUO) This product is sold for laboratory research use only, not for human or in-vivo use.
Form		Biotin Labeled IgG Fraction (Stored in PBS + 50% Glycerol; no preservatives or carrier proteins)
Host		Beta Amyloid 42 Polyclonal Antibody, Biotin Labeled IgG Fraction (SIGNET)Rabbit
Specificity		Covance’s rabbit anti beta amyloid (Aβ) 42 antibody is specific for the C-terminus of Aβ 42. The rabbit anti Aβ 42 reacts extremely well with the 42 isoform. The rabbit anti Aβ 42 antibody does not cross-react with Aβ 40 or APP. Altered levels of Aβ isoforms, specifically the Aβ 40 and Aβ 42 have been shown in the brain tissues and CSF of Alzheimer’s Disease patients. This antibody was generated against a peptide conjugated to keyhole limpet hemocyanin.
Uses		This antibody is effective in immunohistochemistry (IHC).
Suggested Working Dilution		The optimal working dilution should be determined for each specific assay condition. IHC: Pretreatment: The epitope must be re-exposed in fixed tissue by pretreatment of tissue using formic acid (70%) for 10-30 minutes at room temperature
Storage		Do not store antibody diluted below 50 ug/mL in the absence of protein (i.e.: add 2% bovine serum albumin). The antibody is best stored undiluted at -20°C to -70°C.
References		Mehta PD, et al. Amyloid beta protein 40 and 42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. Neurosci Lett 304(1-2):102-6, 2001. Schupf N, et al. Elevated plasma amyloid beta-peptide 42 and onset of dementia in adults with Down syndrome. Neurosci Lett 301(3):199-203, 2001. Mehta PD, et al. Plasma and cerebrospinal fluid levels of amyloid beta proteins 40 and 42 in Alzheimer disease. Arch Neurol 57(1):100-5, 2000. Beta Amyloid 42 Polyclonal Antibody, Biotin Labeled IgG Fraction (SIGNET)Tapiola T, et al. Relationship between apoE genotype and CSF beta-amyloid (42) and tau in patients with probable and definite Alzheimers disease. Neurobiol Aging 21(5):735-40, 2000. Emmerling MR, et al. Traumatic brain injury elevates the Alzheimers amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury. Ann NY Acad Sci 903:118-22, 2000. Potempska A, et al. Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides. Amyloid 6(1):14-21, 1999. Mayeux R, et al. Plasma amyloid beta-peptide 42 and incipient Alzheimers disease.Ann Neurol. 46(3):412-6, 1999.
Warranty/Conditions		Covance products may not be resold or modified for resale without prior written approval.