Beta Amyloid, 1-16 (6E10) Monoclonal Antibody Low Endotoxin, Purified Exclusively Provided by Covance_详细资料

产品信息

靶点：来电咨询浓度： 1mg/1ml 应用范围：科研使用宿主： Goat，Rabbit，Mouse 适应物种：人，大鼠，小鼠，兔标记物：见说明书克隆性：多克隆保存条件： -20℃保存形态：液态/粉状

Beta Amyloid, 1-16 (6E10) Monoclonal Antibody Low Endotoxin, Purified Exclusively Provided by Covance保存于运输说明：

Store at -20°C or below

详细信息：

Description Beta Amyloid (Aβ) Monoclonal Antibody, 6E10
Covance is the Exclusive Provider of this Antibody Product

Intended Use **Research Use Only (RUO)**

This product is sold for laboratory research use only, not for human or in-vivo use.

Clone Beta Amyloid, 1-16 (6E10) Monoclonal Antibody Low Endotoxin, Purified Exclusively Provided by Covance6E10

Form Protein G Purified Antibody (in PBS; no preservatives or carrier proteins)Endotoxin level < 0.5 EU/mL

Host Mouse

Species Reactivity Human

IsoType IgG1

[Ab] 1 mg/mL

Specificity This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS). Beta amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Covances beta amyloid antibody 6E10 reacts to the abnormally processed isoforms, as well as precursor forms.

Uses This antibody is effective in immunoblotting, immunohistochemistry (IHC), immunoprecipitation (IP), and ELISA.

Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition.

IHC:
Tissue Sections: Formalin-fixed human paraffin-embedded brain sections
Pretreatment: Formic acid (70%) for 10-30 minutes at room temperature

Storage Beta Amyloid, 1-16 (6E10) Monoclonal Antibody Low Endotoxin, Purified Exclusively Provided by CovanceStore at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers.

References Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci USA Feb 25, 2009.

Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11(5):556-61, 2005.

Oddo S, et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer’s disease. PNAS 102(8):3046-51, 2005.

Fratta P, et al. Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers. Neurology 63:1114-1117, 2004.

Funamoto S, et al. Truncated carboxyl-terminal fragments of beta- Amyloid precursor protein are processed to Amyloid beta-proteins 40 and 42. Biochem 43:13523-13540, 2004.

Herzig M, et al. Abeta is targeted to the vasculature in a mouse model of heredity cerebral hemorrhage with amyloidosis. Nat. Neuro. 7(9):954-959, 2004.

Kim KS, et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Comm. 2:121-130, 1988.

Kim KS, et al. Neurosci. Res. Comm. 7:113, 1988.

Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval.

Beta Amyloid, 1-16 (6E10) Monoclonal Antibody Low Endotoxin, Purified Exclusively Provided by Covance

xy-15096R   C20orf15120号染色体开放阅读框151抗体
xy-15117R   c20orf7820号染色体开放阅读框78抗体
xy-15103R   C20orf18720号染色体开放阅读框187抗体
xy-15126R   C21orf5921号染色体开放阅读框59抗体
xy-15097R   C20orf152 20号染色体开放阅读框152抗体
xy-15098R   C20orf16520号染色体开放阅读框165抗体
xy-15099R   C20orf16620号染色体开放阅读框166抗体
xy-15100R   C20orf17320号染色体开放阅读框173抗体
xy-15106R   C20orf2420号染色体开放阅读框24抗体
xy-15109R   C20orf30 20号染色体开放阅读框30抗体
xy-15111R   C20orf420号染色体开放阅读框4抗体
xy-15113R   C20orf720号染色体开放阅读框7抗体
xy-15118R   C20orf79 20号染色体开放阅读框79抗体
xy-15119R   C20orf9420号染色体开放阅读框94抗体
xy-15125R   C21orf3721号染色体开放阅读框37抗体
xy-15132R   C22orf15 22号染色体开放阅读框15抗体
xy-15131R   C22orf1322号染色体开放阅读框13抗体
xy-15134R   C22orf2622号染色体开放阅读框26抗体
xy-15142R   C2b补体C2b链多肽抗体
xy-15147R   C2orf162号染色体开放阅读框16抗体
xy-15148R   C2orf27 2号染色体开放阅读框27抗体
xy-12989R   phospho-delta 1 Catenin (Ser268)磷酸化δ连环蛋白抗体
xy-12990R   phospho-delta 1 Catenin (Thr310)磷酸化δ连环蛋白抗体
xy-12991R   phospho-delta 1 Catenin (Thr916)磷酸化δ连环蛋白抗体
xy-12992R   phospho-delta 1 Catenin (Tyr228)磷酸化δ连环蛋白抗体
xy-12993R   phospho-delta 1 Catenin (Tyr291)磷酸化δ连环蛋白抗体
xy-12994R   phospho-delta 1 Catenin (Tyr96)磷酸化δ连环蛋白抗体
xy-15140R   C22orf43 22号染色体开放阅读框43抗体
xy-15143R   C2CD3C2CD3蛋白抗体
xy-10136R   Caspase 14半胱胺酸蛋白酶蛋白14抗体
xy-15178R   C3orf553号染色体开放阅读框55抗体
xy-15181R   C3orf653号染色体开放阅读框65抗体
xy-15165R   C3orf14 3号染色体开放阅读框14抗体
xy-15167R   C3orf203号染色体开放阅读框20抗体
xy-15169R   C3orf23 3号染色体开放阅读框23抗体
xy-15173R   C3ORF31 3号染色体开放阅读框31抗体
xy-15174R   C3orf323号染色体开放阅读框32抗体
xy-15176R   C3orf363号染色体开放阅读框36抗体

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Beta Amyloid, 1-16 (6E10) Monoclonal Antibody Low Endotoxin, Purified Exclusively Provided by Covance

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Description		Beta Amyloid (Aβ) Monoclonal Antibody, 6E10 Covance is the Exclusive Provider of this Antibody Product
Intended Use		Research Use Only (RUO) This product is sold for laboratory research use only, not for human or in-vivo use.
Clone		Beta Amyloid, 1-16 (6E10) Monoclonal Antibody Low Endotoxin, Purified Exclusively Provided by Covance6E10
Form		Protein G Purified Antibody (in PBS; no preservatives or carrier proteins)Endotoxin level < 0.5 EU/mL
Host		Mouse
Species Reactivity		Human
IsoType		IgG1
[Ab]		1 mg/mL
Specificity		This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS). Beta amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Covances beta amyloid antibody 6E10 reacts to the abnormally processed isoforms, as well as precursor forms.
Uses		This antibody is effective in immunoblotting, immunohistochemistry (IHC), immunoprecipitation (IP), and ELISA.
Suggested Working Dilution		The optimal working dilution should be determined for each specific assay condition. IHC: Tissue Sections: Formalin-fixed human paraffin-embedded brain sections Pretreatment: Formic acid (70%) for 10-30 minutes at room temperature
Storage		Beta Amyloid, 1-16 (6E10) Monoclonal Antibody Low Endotoxin, Purified Exclusively Provided by CovanceStore at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers.
References		Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci USA Feb 25, 2009. Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11(5):556-61, 2005. Oddo S, et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer’s disease. PNAS 102(8):3046-51, 2005. Fratta P, et al. Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers. Neurology 63:1114-1117, 2004. Funamoto S, et al. Truncated carboxyl-terminal fragments of beta- Amyloid precursor protein are processed to Amyloid beta-proteins 40 and 42. Biochem 43:13523-13540, 2004. Herzig M, et al. Abeta is targeted to the vasculature in a mouse model of heredity cerebral hemorrhage with amyloidosis. Nat. Neuro. 7(9):954-959, 2004. Kim KS, et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Comm. 2:121-130, 1988. Kim KS, et al. Neurosci. Res. Comm. 7:113, 1988.
Warranty/Conditions		Covance products may not be resold or modified for resale without prior written approval.