D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)_详细资料

产品信息

靶点：来电咨询浓度： 1mg/1ml 应用范围：科研使用宿主： Goat，Rabbit，Mouse 适应物种：人，大鼠，小鼠，兔标记物：见说明书克隆性：多克隆保存条件： -20℃保存形态：液态/粉状

D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)详细信息：

Description Purified Monoclonal Antibody against Lymphatic Endothelial Marker
(Formerly Signet Catalog Nos: 730-001, 730-01, 730-16 L1 Predilute, 730-26 L2 Predilute)

Intended Use ** In Vitro Diagnostic (IVD) **

Clone D2-40

Form Purified Antibody (in 0.01M PBS + 0.1% NaN3 + 1% BSA)

Host Mouse

Species Reactivity Human

IsoType D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)IgG1

Specificity Clone D2-40 reacts with a O-linked sialoglycoprotein (MW 40kDa) found on lymphatic endothelium, fetal testis and on the surface of testicular germ cell tumors. In recent studies clone D2-40 (D240) has shown staining in lymphatic channel endothelium but not in the adjacent capillary.

This antibody was developed using M2A.

Concentrated Format:
SIG-3730-100 [0.1 mL]
SIG-3730-1000 [1 mL]

Prediluted Formats:
SIG-3730-16 [6 mL]
SIG-3730-26 [6 mL]
Both are ready-to-use with either a Biotin-based (USA Ultra Streptavidin Detection, SIG-32250) or Biotin-free (ACUITYAdvanced Polymer Detection, SIG-32902) detection systems.

Uses This antibody is effective in immunoblotting and immunohistochemistry (IHC).

Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition.

Western blot: 0.1 - 0.5 ug/mL

IHC: ≥1:40 (concentrated format) for Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
Tissue Sections: Formalin-fixed, paraffin-embedded tissues, frozen sections
Pretreatment: Not required
Incubation: 60 minutes at room temperature

Storage D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)Store between 2-8°C.

References Choi WW, et al. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF family gene expression. Mod Pathol 18:143-52, 2005.

Chu, AY, et al. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol 18:105-110, 2005.

Dumoff KL, et al. Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix. Mod Pathol 18:97-104, 2005.

Galambos C, Nodit L. Identification of lymphatic endothelium in pediatric vascular tumors and malformations. Ped Dev Pathol 8(2):181-9, 2005.

Fogt F, et al. Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep 11:47-50, 2004.

Fogt F, et al. Observation of lymphatic vessels in orbital fat of patients with inflammatory conditions: A form fruste of lymphangiogenesis? Int J Molec Med 13:681-683, 2004.

Franchi A, et al. Tumor lymphangiogenesis in head and neck squamous cell carcinoma.Cancer 101(5):973-978, 2004.

Franke FE, et al. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol 31:362-367, 2004.

Giorgadze TA, et al. Lymphatic vessel density is significantly increased in melanoma. J Cutan Pathol 31:672-677, 2004.

Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval.

D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)

xyA340Hu   蛛毒素受体3(LPHN3)检测试剂盒   检测范围
xyA425Hu   突触素(SYP)检测试剂盒   检测范围
xyA444Hu   桥粒芯糖蛋白3(DSG3)检测试剂盒   检测范围
xyA464Hu   盐皮质激素受体(MR)检测试剂盒   检测范围
xyA488Hu   角蛋白5(KRT5)检测试剂盒   检测范围
xyA556Hu   角蛋白7(KRT7)检测试剂盒   检测范围
xyA792Hu   拓扑异构酶Ⅱ(TOP2)检测试剂盒   检测范围
xyA944Hu   岩藻糖基转移酶3(FUT3)检测试剂盒   检测范围
xyB059Hu   岩藻糖基转移酶4(FUT4)检测试剂盒   检测范围
xyB182Hu   滑行蛋白α(TXLNα)检测试剂盒   检测范围
xyB228Hu   整合素α2(ITGα2)检测试剂盒   检测范围
xyB285Hu   整合素α6(ITGα6)检测试剂盒   检测范围
xyB313Hu   整合素α1(ITGα1)检测试剂盒   检测范围
xyB440Hu   整合素β4(ITGβ4)检测试剂盒   检测范围
xyB608Hu   核受体亚家族3C组成员1(NR3C1)检测试剂盒   检测范围
xyB678Hu   淋巴细胞抗原9(LY9)检测试剂盒   检测范围
xyB853Hu   基质金属蛋白酶19(MMP19)检测试剂盒   检测范围
xyB905Hu   白介素7受体(IL7R)检测试剂盒   检测范围
xyB952Hu   组蛋白乙酰基转移酶1(HAT1)检测试剂盒   检测范围
xyC048Hu   磷脂酶B(PLB)检测试剂盒   检测范围
xyC049Hu   磷脂酶D(PLD)检测试剂盒   检测范围
xyC077Hu   层黏连蛋白α4(LAMα4)检测试剂盒   检测范围
xyC080Hu   层粘连蛋白β2(LAMβ2)检测试剂盒   检测范围
xyC097Hu   整合素α11(ITGα11)检测试剂盒   检测范围
xyC169Hu   神经秩蛋白(NRTN)检测试剂盒   检测范围
xyC206Hu   组蛋白脱乙酰基酶1(HDAC1)检测试剂盒   检测范围
xyC260Hu   融合蛋白(FUS)检测试剂盒   检测范围
xyC270Hu   7-脱氢胆固醇还原酶(DHCR7)检测试剂盒   检测范围
xyC276Hu   氨基酰化酶1(ACY1)检测试剂盒   检测范围
xyC281Hu   腺苷激酶(ADK)检测试剂盒   检测范围
xyC295Hu   无羊膜蛋白(AMN)检测试剂盒   检测范围
xyC304Hu   Attractin蛋白(ATRN)检测试剂盒   检测范围
xyC340Hu   胱天蛋白酶6(CASP6)检测试剂盒   检测范围
xyC393Hu   皮质醇稳定蛋白(CORT)检测试剂盒   检测范围
xyC397Hu   羧肽酶M(CPM)检测试剂盒   检测范围
xyC411Hu   肘臀蛋白(CUBN)检测试剂盒   检测范围
xyC426Hu   细胞球蛋白(CYGB)检测试剂盒   检测范围
xyC480Hu   脂筏特征蛋白2(FLOT2)检测试剂盒   检测范围
xyC520Hu   透明质酸合酶1(HAS1)检测试剂盒   检测范围
xyC551Hu   Janus激酶1(JAK1)检测试剂盒   检测范围

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Description		Purified Monoclonal Antibody against Lymphatic Endothelial Marker (Formerly Signet Catalog Nos: 730-001, 730-01, 730-16 L1 Predilute, 730-26 L2 Predilute)
Intended Use		In Vitro Diagnostic (IVD)
Clone		D2-40
Form		Purified Antibody (in 0.01M PBS + 0.1% NaN3 + 1% BSA)
Host		Mouse
Species Reactivity		Human
IsoType		D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)IgG1
Specificity		Clone D2-40 reacts with a O-linked sialoglycoprotein (MW 40kDa) found on lymphatic endothelium, fetal testis and on the surface of testicular germ cell tumors. In recent studies clone D2-40 (D240) has shown staining in lymphatic channel endothelium but not in the adjacent capillary. This antibody was developed using M2A. Concentrated Format: SIG-3730-100 [0.1 mL] SIG-3730-1000 [1 mL] Prediluted Formats: SIG-3730-16 [6 mL] SIG-3730-26 [6 mL] Both are ready-to-use with either a Biotin-based (USA Ultra Streptavidin Detection, SIG-32250) or Biotin-free (ACUITYAdvanced Polymer Detection, SIG-32902) detection systems.
Uses		This antibody is effective in immunoblotting and immunohistochemistry (IHC).
Suggested Working Dilution		The optimal working dilution should be determined for each specific assay condition. Western blot: 0.1 - 0.5 ug/mL IHC: ≥1:40 (concentrated format) for Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250). Tissue Sections: Formalin-fixed, paraffin-embedded tissues, frozen sections Pretreatment: Not required Incubation: 60 minutes at room temperature
Storage		D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)Store between 2-8°C.
References		Choi WW, et al. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF family gene expression. Mod Pathol 18:143-52, 2005. Chu, AY, et al. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol 18:105-110, 2005. Dumoff KL, et al. Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix. Mod Pathol 18:97-104, 2005. Galambos C, Nodit L. Identification of lymphatic endothelium in pediatric vascular tumors and malformations. Ped Dev Pathol 8(2):181-9, 2005. Fogt F, et al. Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep 11:47-50, 2004. Fogt F, et al. Observation of lymphatic vessels in orbital fat of patients with inflammatory conditions: A form fruste of lymphangiogenesis? Int J Molec Med 13:681-683, 2004. Franchi A, et al. Tumor lymphangiogenesis in head and neck squamous cell carcinoma.Cancer 101(5):973-978, 2004. Franke FE, et al. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol 31:362-367, 2004. Giorgadze TA, et al. Lymphatic vessel density is significantly increased in melanoma. J Cutan Pathol 31:672-677, 2004.
Warranty/Conditions		Covance products may not be resold or modified for resale without prior written approval.