7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
im
portant Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Aspartyl/asparaginyl beta-hydroxylase (ASPH) is a widely-expressed type II membrane protein involved in calcium homeostasis. Located in the endoplasmic reticulum, ASPH specifically hydroxylates an Asp or Asn residue in the epidermal growth factor-like (EGF) domains of several proteins, using iron as a cofactor. The ASPH gene encodes 3 proteins, ASPH, Junctin, and Junctate (or Humbug), that differ significantly in their C-terminal domains. These ASPH gene products are expressed as five trans
cript variants that differ by their roles in calcium storage and release, hydroxylation capabilities, and tissue specificity. While all ASPH variants are expressed in skeletal muscle, o
nly some are detected in heart, brain, pancreas, placenta, lung, liver, and kidney tissues. In the lumen of the endoplasmic reticulum, ASPH can be processed into two different forms.
Function : ASPH is thought to play an im
portant role in calcium homeostasis. Alternative splicing of this gene results in five trans
cript variants which vary in protein translation, the coding of catalytic domains, and tissue ex
pression. Variation among these trans
cripts impacts their functions which involve roles in the calcium storage and release process in the endoplasmic and sarcoplasmic reticulum as well as hydroxylation of aspartic acid and asparagine in epidermal growth factor like domains of various proteins.
Subunit : Mo
nomer (By similarity). Isoform 8 interacts with ORAI1 and STIM1.
Subcellular Location : Isoform 1: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Isoform 8: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Tissue Specificity : Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level).
二氢小檗碱 483-15-8售后服务Similarity : Endoplasmic reticulum; endoplasmic reticulum membrane; Single-pass type II membrane protein.
Databa
se l
inks : UniProtKB/Swiss-Prot: Q12797.3
英文名称 Anti-AVPR2