holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex co
nsisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.
Subcellular Location : Nucleus.
Tissue Specificity : Highly expressed in testis and placenta. Low levels in bro
nchial epithelial cells.
Post-translatio
nal modifications : Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.
Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
Similarity : Belo
ngs to the cyclin family. Cyclin E subfamily.
Databa
se l
inks : UniProtKB/Swiss-Prot: P24864.2
细胞周期素E是调控细胞G-1→S期转变的关键因素。由于在多种肿瘤中的不适当表达,细胞周期素E现在已明确为原癌基因。
英文名称 Anti-Alpha s2 Casein
中文名称 α-s2酪蛋白抗体
别 名 Alpha s2 Casein; Alpha-s2-Casein; CSN1S2; CASA2_BOVIN; Casocidin-1; Casocidin-I.
浓 度 1mg/1ml
规 格 0.2ml/200μg
十二烷基磺酸钠100g规格抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Cow, Sheep,
产品类型 一抗