complex, forming an alkalinization-activated Ca2+-selective channel. Mutations in any of the genes encoding CatSper family proteins can result in male infertility. CatSper3 plays an im
portant role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization.
Function : Voltage-gated calcium channel that plays a central role in calcium-dependent physiological respo
nses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by me
tabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additio
nal negative shift. Also activated by the elevation of intracellular pH.
Subunit : Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Compo
nent of the CatSper complex. Interacts with CATSPER1.
Subcellular Location : Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
Tissue Specificity : Testis-specific.
Similarity : Belo
ngs to the cation channel sperm-associated (TC 1.A.1.19) family.
Databa
se l
inks : UniProtKB/Swiss-Prot: Q86XQ3
英文名称 Anti-CATSPER4
营养肉汤(NB)颗粒规格中文名称 阳离子通道精子相关蛋白4抗体
别 名 CTSR4_HUMAN; Cation channel sperm-associated protein 4; CatSper4; CatSper-4; cation channel, sperm-associated 4.
浓 度 1mg/1ml
规 格 0.2ml/200μg