地中海热蛋白MEFV抗体,Anti-MEFV抗体

背景介绍：This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. 

Function:
Involved in innate immunity and the inflammatory response. Interacts with several components of the inflammasome complex, a large oligomeric structure which recruits and activates CASP1 and ultimay induces maturation of cytokines such as IL1B. However, the exact role of MEFV in the inflammatory pathway is uncertain as contradictory effects on IL1B processing have been reported in different experimental systems. Has been shown to activate IL1B production (Ref.13). Has also been shown to inhibit IL1B production (Ref.14, Ref.15). Also required for PSTPIP1-induced PYCARD oligomerization and for formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Can reduce PYCARD-induced apoptosis. Recruits PSTPIP1 to pyroptosomes, and required for PSTPIP1 oligomerization.

别名：FMF; Marenostrin; Mediterranean fever; Mediterranean fever protein; MEF; Mefv; MEFV_HUMAN; Pyrin; TRIM20. 

地中海热蛋白MEFV抗体,Anti-MEFV抗体简单介绍：

产品编号：BYK-18750R

英文名称：Anti-MEFV
中文名称：地中海热蛋白MEFV抗体

产品规格：50ul；100ul；200ul；1ml，品质保证

抗体来源 Rabbit or Mouse

克隆类型 Polyclonal or Monoclonal

交叉反应、产品应用 （具体交叉反应与产品应用请或添加客服直接索取）

性    状 Lyophilized or Liquid
浓    度 1mg/ml

地中海热蛋白MEFV抗体,Anti-MEFV抗体产品信息：

博研生物小课堂：

常用激光器对应荧光素的选择：

蓝色激光器荧光素（488nm）：Alexa Fluor 488、FITC、PerCP、PerCP-Cy5.5、PE、PE-Cy5.5、PE-Cy5、PE-Cy7

红色激光器荧光素（633nm）：APC、Cy5、APC-Cy5.5、APC-Cy7、Alexa Fluor 647

黄色激光器荧光素（561nm）：PE、PE-Cy5.5、PE-Cy5、PE-Cy7、Cy3、Alexa Fluor 555、Alexa Fluor 594

流式细胞术Flowcytometry：理：流式细胞术(flowcytometry FCM)是对单个细胞或其他生物微粒进行快速定量分析和分选的一门技术。在分析或分选过程中，包绕在流动液体中处理过的单个细胞或微粒通过聚焦的光源，产生电信号，这些信号代表光散射、荧光等参数，以此测定出细胞或微粒的物理和化学性质，并可根据这些性质分选出高纯度的细胞亚群，以对其进一步的培养或分析。

应用：流式细胞术的功能决定了其在免疫学基础研究中的广泛应用，目前在临床上主要用于细胞表型分析、造血系肿瘤诊断和分型、移植前配型及与免疫有关疾病分析等。

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