焦油紫CAS号：10510-54-0

焦油紫CAS号：10510-54-0   
英文名称：Cresyl Violet acetate；9-Amino-5-imino-5H-benzo(a)phenoxazine acetate salt   
其他名称：醋酸甲酚紫；甲酚紫；甲酚青莲；甲酚紫乙酸盐   
CAS号：10510-54-0    
C18H15N3O3=321.33   
级别：BR   
含量Dye content：～70%   
熔点：140～143℃   
性状(以下信息仅供参考)：绿色或黑色粉末，溶于水   
用途：本品仅供科研，不得用于其它用途   
保存：RT

焦油紫CAS号：10510-54-0储存条件：
避光、干燥阴凉处封闭贮存,严禁与有毒、有害物品混放、混运。本品为非危险 产品可按一般化学品运输,轻搬动轻放,防止日晒、雨淋！受热、受潮、受光后易丧失活力,保存期短,因此贮存和运输条件比较苛刻。
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存储：应贮存在干燥清洁避光的环境中，严禁与有毒物质混放，以免污染（保质期为两年）。
焦油紫CAS号：10510-54-0主要优级纯、分级纯和化学纯3种：
（1）优级纯（GR：Guaranteed reagent），又称一级品或保证试剂，99.8%，这种试剂纯度zui高，杂质含量zui低，适合于重要精密的分析工作和科学研究工作，使用绿色瓶签。
（2）分析纯（AR），又称二级试剂，纯度很高，99.7%，略次于优级纯，适合于重要分析及一般研究工作，使用红色瓶签。
（3）化学纯（CP），又称三级试剂，≥ 99.5%，纯度与分析纯相差较大，适用于工矿、学校一般分析工作。使用蓝色（深蓝色）标签。
（4）实验试剂（LR：Laboratory reagent），又称四级试剂。
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产品介绍 Nudel is important for normal cortical development. It is invovled in microtubule organization, nuclear translocation, and neuronal positioning in concert with various other factors (including Lis1, Pafah1b1, Pahfah1b2, dynein, dynorphin A and cdk5). Western blot analysis of mouse tissues shows abundant expression of Nudel in brain and testis, and much lower expression in heart, liver, kidney, and skeletal muscle. In fractionated rat brain, Nudel and Lis1 are both found in fractions enriched for postsynaptic density proteins. Immunostaining of embryonic day 18 mouse brain sections revealed staining of migrating neurons and thalamocortical axons of the intermediate zone of the developing cerebral cortex, as well as several other developing brain regions. The deduced protein contains 345 amino acids and has a calculated molecular mass of 38.4 kDa. It has a coiled coil motif (residues 19 to 201), followed by several potential phosphorylation sites for casein kinase II, protein kinase C or CDK5. Nudel shares about 50% identity with mouse and human NUDE proteins.
Function : Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.
Subunit : Interacts with YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts with microtubules (By similarity). Self-associates. Interacts with DISC1, dynein, dynactin, tubulin gamma, KATNA1, KATNB1, PAFAH1B1, PCM1 and PCNT. Interacts (via C-terminus) with CENPF. Interacts with ZNF365.
Subcellular Location : Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner.
Tissue Specificity : Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
Post-translational modifications : Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE.
Palmitoylation at Cys-273 reduces affinity for dynein.
Similarity : Belongs to the nudE family.
Database links : UniProtKB/Swiss-Prot: Q9GZM8.1
ZX粒蛋白Nudel是动物细胞中，ZX体微管组织的主要细胞器，是细胞质动力蛋白调节因子在ZX体组装及徽管组织中发挥重要作用。
英文名称  Anti-phospho-NTRK2/TrkB (Tyr515)
中文名称  磷酸化酪氨酸激酶B抗体
别    名  TrkB (Phospho-Tyr515); NTRK2(phospho Y515); p-NTRK2(Y515); TrkB; Tyrosine Receptor Kinase B; Tyrosine kinase,Pyk2; BDNF tropomyosine receptor kinase B; BDNF/NT 3 growth factors receptor; BDNF/NT-3 growth factors receptor; Brain derived neurotrophic factor receptor; GP145 TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP95 TrkB; Neurotrophic tyrosine kinase receptor type 2; Neurotrophin receptor tyrosine kinase type 2; NTRK 2; Ntrk2; NTRK2_HUMAN; Obesity, hyperphagia, and developmental delay, included; RATTRKB1; Tkrb; Trk B; Trk-B; TRKB; TrkB tyrosine kinase; TRKB1; tyrosine kinase receptor B; Tyrosine receptor kinase B.
浓    度  1mg/1ml
规 格  0.1ml/100μg
抗体来源  Rabbit 
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit
产品类型  一抗  磷酸化抗体  
研究领域  免疫学 神经生物学 信号转导 转录调节因子 激酶和磷酸酶 
蛋白分子量  predicted molecular weight: 92kDa