变色酸 CAS号：148-25-4

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变色酸 CAS号：148-25-4  
英文名称：Chromotropic acid；1,8-Dihydroxynaphthylene-3,6-disulfonic acid；4,5-Dihydroxynaphthalene-2,7-disulphonic acid    
其他名称：铬变酸；1,8-二羟基萘-3,6-二磺酸；4，5-二羟基-2，7-萘二磺酸；比色酸    
CAS号：148-25-4    
C10H8O8S2=320.30   
级别：CP   
灵敏度试验：合格   
盐酸溶解试验：合格   
性状(以下信息仅供参考)：白色或灰白色针状结晶或粉末。接触空气易变色。实际商品常带有色泽。溶于盐酸和水   
用途：本品仅供科研，不得用于其它用途。(以下用途仅供参考)铬、钛和甲醛的光度测定；铬、钛、酸盐、甲醛、硝酸盐和亚硝酸盐的检定；偶氮染料中间体    
保存：RT，避光
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eventual recycling of the SNARE complex for subsequent membrane fusion (3,4).
Function : Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.
Subunit : Homohexamer. Interacts with GABARAP and GABARAPL2. Interacts with GRIA2. Interacts with PLK2, leading to disrupt the interaction with GRIA2. Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16 (By similarity).
Subcellular Location : Cytoplasm.
Post-translational modifications : Phosphorylation at Ser-569 interferes with homohexamerization (By similarity).
Similarity : Belongs to the AAA ATPase family.
Database links : UniProtKB/Swiss-Prot: P46459.3
英文名称  Anti-Nephrin
中文名称  肾小球细胞粘附分子受体抗体
别    名  CNF; Nephrin; Nephrosis 1 congenital Finnish type; Nephrosis 1, congenital, Finnish type (nephrin); NPHN; NPHN_HUMAN; NPHS 1; NPHS1; Renal glomerulus specific cell adhesion receptor; Renal glomerulus-specific cell adhesion receptor.
浓    度  1mg/1ml
规 格  0.1ml/100μg  0.2ml/200μg
抗体来源  Rabbit 
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Dog, Pig, Cow
产品类型  一抗   
变色酸 CAS号：148-25-4亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2. Nephrin, a recently identified protein is a member of a group of podocyte proteins that constitute major component of the slit diaphragm especially in the foot process. Nephrin, a cell adhesion molecule, may play a crucial role in maintaining the glomerular filtration barrier. Recent studies have suggested that mutations in the gene for Nephrin reportedly lead to congenital nephrosis. Three novel podocyte proteins, Podocin, Nephrin and alpha Actinin 4 have been identified in congenital and experimental models of proteinuria. The role of Nephrin in anti apoptotic activity in podocyte slit diaphragm is believed to be associated with vascular endothelial derived growth factors VEGF signaling.
Function : Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.
Subunit : Interacts with CD2AP (via C-terminal domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a