规格: | 0.5mg | 产品价格: | 8415.00 |
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规格: | 1mg | 产品价格: | 15015.00 |
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Catalog Number H-4146
Synonyms AF12198
Molecular Formula C₉₆H₁₂₃N₁₉O₂₂
Relative Molecular Mass 1895.15
CAS Registry Number [185413-30-3]
One Letter Code Ac-FEWTPGWYQ-Aze-YALPL-NH₂
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Cytokines/Chemokines & their Receptors
产品描述
AF12198 exhibited both in vitro and in vivo IL-1 antagonist activity. It selectively bound the human type I IL-1 receptor but not the human type II receptor or the murine type I receptor. In vitro, AF12198 inhibited IL-1-induced IL-8 production by human dermal fibroblasts with an IC₅₀ of 25 nM and IL-1-induced intercellular adhesion molecule-1 expression by endothelial cells with an IC₅₀ of 9 nM. In vivo it blocked ex-vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6. This is the first small molecule which shows IL-1 receptor antagonist activity in vivo.
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温馨提示:不可用于临床ZL。