GLP-1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat) trifluoroacetate salt

产品描述
Glucagon-like peptide-1 (GLP-1) is efficiently degraded by the enzyme dipeptidyl peptidase IV (DPP IV), yielding the major metabolite GLP-1 (9-36) amide. GLP-1 (9-36) amide does not affect glucose disposal in mice either in the presence or absence of intact GLP-1 receptors or in the presence or absence of stimulated insulin levels. This suggests that the GLP-1 metabolite is not involved in the regulation of glucose homeostasis. Elahi et al. have shown that this GLP-1 metabolite acts as a weak insulinotropic agent and inhibits hepatic glucose production.

论文引用
• M.J.Bak et al., Diabetes Obes. Metab., 16, 1155 (2014)
• J.Hou et al., J. Cereb. Blood Flow Metab., 32, 2201 (2012)
• T.Ma et al., J. Neurosci., 32, 13701 (2012)
• M.Nagashima et al., Diabetologia, 54, 2649 (2011)
• K.Ban et al., Endocrinology, 151, 1520 (2010)
• S.M.Gardiner et al., Br. J. Pharmacol., 161, 92 (2010)
• S.M.Gardiner et al., Br. J. Pharmacol., 161, 92 (2010)
• I.Hadjiyanni et al., Diabetologia, 53, 730 (2010)

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