Integrin beta 1 (ITGB1) 抗体 (Biotin)

Integrin beta 1 (ITGB1) 抗体 (Biotin)抗原    
Integrin beta 1 (ITGB1)
别名     cd29, fnrb, gpiia, itgb1, mdf2, msk12, vla-beta, vlab, CD29, 4633401G24Rik, AA409975, AA960159, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
适用    
 其他选择 人, 猪, 犬
宿主    
 其他选择 小鼠
克隆类型 (克隆位点)    
单克隆 (MEM-101A)
标记    
 其他选择 Biotin
应用范围    
 其他选择 流式细胞分析技术（FACS）
Pubmed     7个引用可参考
规格     0.1 mg
发货至     ZG (更改)
发货时间     23至29个工作日
产品编号 yb94055
产品细节 Integrin beta 1 (ITGB1) 抗体 (Biotin)
免疫原     Raji Burkitt's lymphoma cell line
克隆位点     MEM-101A
亚型     IgG1
特异性     The antibody MEM-101A reacts with CD29 (integrin beta1 chain), a 130 kDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 is broadly expressed on majority of hematopoietic and non-hematopoietic cells (leukocytes, platelets, fibroblasts, endothelial cells, epithelial cells and mast cells).HLDA VI, WS Code AS A048
无交叉反应     小鼠
产品特性     The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
目标详细情况 Integrin beta 1 (ITGB1) 抗体 (Biotin)
别名     ITGB1
背景     CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.
使用细节 Integrin beta 1 (ITGB1) 抗体 (Biotin)
应用备注     Biotinylated antibody is designed for indirect immunofluorescence analysis by Flow Cytometry. Suggested working dilution is 1: 1000. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Working concentrations should be determined by the investigator.
限制     仅限研究用
贮存及处理 Integrin beta 1 (ITGB1) 抗体 (Biotin)
浓度     1 mg/mL
缓冲液     Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
储存液     Sodium azide
注意事项     WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
注意事项    Do not freeze. 
Avoid prolonged exposure to light.
储存条件     4 °C
储存方法     Store at 2-8 °C. Do not use after expiration date stamped on vial label.