Acerbon; Carace; Coric; Novatec; Prinil; Tensopril; Vivatec; Zestril|Lisinopril is an enalapril analog that inhibits angiotensin-converting enzyme (ACE), exhibiting antihypertensive, cardioprotective, and anti-fibrotic activities. Lisinopril is clinically used to treat hypertension, congestive heart failure (CHF), myocardial infarction, and retinal disorders associated with diabetes. In vivo, lisinopril decreases matrix metalloproteinase 2 (MMP2) activity, inhibits left ventricular dilation, and suppresses myocardial hypertrophy, preventing changes in contractility. In other animal models, this compound decreases hydroxyproline levels and inhibits paraquat-induced lung fibrosis.|C21H31N3O5 2H2O|441.52||Ambient|Soluble in water (100 mg/mL) or DMSO (6.5mg/mL with heating and sonication), methanol (14 mg/mL). Insoluble in ethanol.
温馨提示:不可用于临床ZL。