Arythmol; Pronon; Rythmol; Rytmonorm|Propafenone is a class Ic anti-arrhythmic compound that inhibits -adrenergic receptors, slows Na+ and Ca2+ influx, and decreases overall cellular excitability. Propafenone inhibits Kv1.4 K+ channels and human cardiac two pore-domain (K2P2) K+ channels. Additionally, propafenone inhibits expression of tyrosinase, TRP-1, and TRP-2, and decreases production of cAMP, suppressing melanogenesis in vitro.|C21H27NO3 HCl|377.91||Ambient|Soluble in basic lower aliphatic alcohols, chloroform and hot water. Slightly soluble in cold water. Insoluble in ether.
温馨提示:不可用于临床ZL。