CDH1 / CD324 / E-cadherin抗体

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is the classical cadherin molecule and contains five cadherin domains of ~110 aa each in the extracellular domain. E-Cad is expressed in the non-neural epithelial tissues as disulfide-linked homodimer, and plays a key role in the organization and integrity of most epithelial tissues, cell differentiation and tissue development. CDH1 interacts directly, via the cytoplasmic domain, with CTNNB1 or JUP to form the PSEN1/cadherin/catenin adhesion complex which connects to the actin skeleton through the actin binding of alpha-catenin. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas (gastric, breast, ovary, endometrium and thyroid).
CDH1 / CD324 / E-cadherin抗体相关产品如下：xy-0666xy    Fibronectin (FN)纤维连结蛋白(多肽抗原)
xy-0734xy    FGF-7/KGF (Keratinocyte growth factor precursor)成纤维细胞生长因子-7/纤维母细胞生长因子 (抗原)
xy-0675xy    FGFR2(Fibroblast Growth Factor Receptor 2)成纤维细胞生长因子受体2抗原
xy-0735xy    FGF-8/HBGF-8 (Fibroblast growth factor 8)成纤维细胞生长因子-8/纤维母细胞生长因子-8 (抗原)
xy-0400xy    GAD-65 (glutamate decarboxylase)谷氨酸脱羧酶-65(C端多肽)
xy-0721xy    Galectin-3 半乳糖凝集素-3(抗原)
xy-0701xy    GCS (glucosylceramide synthase, GCS)葡萄糖神经酰胺合成酶（抗原）
xy-0639xy    GFP绿色荧光蛋白
xy-0725xy    ER-alpha雌激素受体alpha
xy-0654xy    GHR (growth hormone receptor)生长激素受体(抗原)
xy-0472xy    GLUT1(Glucose transporter type 1)葡萄糖转运蛋白1（抗原）
xy-0618xy    hypothetical protein (LOC55652)hypothetical protein 抗原
xy-0402xy    HCCR-1(BRI3 binding protein)人宫颈癌基因/bri3结合蛋白(抗原)
xy-0343xy    pre S1/S2 protein [HBV]乙肝病毒pre S1/乙肝病毒pre S2(抗原)
xy-0728xy    HCV-HCBP1/ACY-3(Hepatitis C virus core-binding protein 1)丙型肝炎病毒核心蛋白结合蛋白-1（抗原）
xy-0746xy    HHV8/ORF50(Human herpesvirus 8 type P)人类疱疹病毒8抗原
xy-0869xy    HHV8/ORF K2/vIL-6(Human herpesvirus 8)人类疱疹病毒8抗原
xy-0737xy    HIF-1Alpha缺氧诱导因子1α 多肽
xy-0483xy    histone H3-like protein组蛋白H3样蛋白多肽
xy-0620xy    histone H3-like protein组蛋白H3样蛋白（C端多肽）
xy-0621xy    histone H3-like protein组蛋白H3样蛋白（N端多肽）
xy-0785xy    HIV-1(human immunodeficiency virus type 1)艾滋病病毒-1/人类免疫缺陷病毒1型(抗原)
xy-0786xy    HIV-1(human immunodeficiency virus type 1)艾滋病病毒-1/人类免疫缺陷病毒1型(抗原)
xy-0887xy    Measles virus protein(Plant2 derived measles virus hemagglutinin protein)麻疹病毒红血球凝集素蛋白多肽
xy-0888xy    Measles virus protein(Plant2 derived measles virus hemagglutinin protein)麻疹病毒红血球凝集素蛋白多肽
xy-0455xy    HSL(hormone-sensitive lipase)荷尔蒙敏感脂肪酸（抗原）
xy-0730xy    HSP-27(Heat Shock Protein 27)热休克蛋白-27(抗原)
xy-0696xy    HSP-90Alpha(Heat Shock Protein 90Alpha )热休克蛋白90α(抗原)
xy-0135xy    HSP-90 Beta (heat sock protein-90 Beta)热休克蛋白-90β （抗原）
xy-0284xy    IASPP(inhibitory member of the ASPP family)肿瘤细胞凋亡ASPP家族的另一个成员(抗原)
xy-0608xy    CD54/ICAM-1细胞间粘附分子-1
xy-0812xy    IL-1 Beta(Interleukin-1 Beta)白介素1β（白细胞介素-1β）(多肽抗原)
xy-0445xy    IL1RAPL1 (Interleukin 1 receptor accessory protein-like 1)白介素受体相关蛋白样1前体蛋白（抗原）