Prealbumin / Transthyretin / TTR抗体

Prealbumin / Transthyretin / TTR抗体产品信息免疫原 :  Recombinant Human Prealbumin / Transthyretin / TTR protein (Catalog#12091-H08H)
 
Antibody Type :  Rabbit Polyclonal Antibody ( Antibody Purification Platform ) 
抗体宿主 : Rabbit IgG
 
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation. 
制备方法 :  Produced in rabbits immunized with purified, recombinant Human Prealbumin / Transthyretin / TTR (rh Prealbumin / Transthyretin / TTR; Catalog#12091-H08H; NP_000362.1; Met 1-Glu 147). Prealbumin / Transthyretin / TTR specific IgG was purified by Human Prealbumin / Transthyretin / TTR affinity chromatography.
Prealbumin / Transthyretin / TTR抗体 Background
Transthyretin, also known as ATTR, Prealbumin, TTR and PALB, is a secreted and cytoplasm protein which belongs to thetransthyretin family. Transthyretin (TTR / PALB) is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Transthyretin (TTR / PALB) has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Defects in TTR / PALB are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system.
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