Purified anti-mouse CD205 (DEC-205)_详细资料

产品信息

克隆性：多克隆保存条件：蓝冰规格： 100 ug

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Purified anti-mouse CD205 (DEC-205)参数介绍>>>>

Clone NLDC-145
Isotype Rat IgG2a, κ
Reactivity Mouse
Immunogen Mouse lymph node tissue
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography.
Concentration 0.5mg/ml
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Applications
FC - Quality tested
IHC, WB, IP - Reported in the literature
Application Notes
Additional reported applications (for relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections¹, Western Blot^1-3, and immunoprecipitation of bone marrow dendritic cell extracts².
"
Application References
1. Witmer-Pack MD, et al. 1995. Cell. Immun. 163:157. (IHC, WB)
2. Swiggard WJ, et al. 1995. Cell. Immun. 165:302. (WB, IP)
3. Bonifaz LC, et al. 2004. J. Exp. Med. 199:815. (WB)
4. Yamazaki S, et al. 2002. J. Immunol. 181:6923. (FC)
5. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC)
Description
CD205, also known as DEC-205, is a 205 kD integral membrane protein homologous to the macrophage mannose receptor. It is a type I cell surface protein that belong to the C-type lectin family. CD205 is expressed at high levels by dendritic cells and thymic epithelial cells. It is also expressed by a number of other cell types, such as B lymphocytes, macrophages, Langerhans cells, bone marrow stromal cells, granulocytes, epithelial cells of pulmonary airways, and the capillaries of the brain. CD205 is a novel endocytic receptor used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to specialized antigen processing. It mediates antigen uptake and presentation and cross-presentation to T cells. It has been reported that CD205 acts as a recognition receptor for dying cells, potentially provides an important pathway for the uptake of self-antigen in the intrathymic environment, and is involved in peripheral tolerance. Antibody-mediated antigen-targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity.
"
Storage The antibody solution should be stored undiluted at 4°C.

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Purified anti-mouse CD205 (DEC-205)

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Clone	NLDC-145
Isotype	Rat IgG2a, κ
Reactivity	Mouse
Immunogen	Mouse lymph node tissue
Formulation	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation	The antibody was purified by affinity chromatography.
Concentration	0.5mg/ml
Recommended Usage	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Applications	FC - Quality tested IHC, WB, IP - Reported in the literature
Application Notes	Additional reported applications (for relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections¹, Western Blot^1-3, and immunoprecipitation of bone marrow dendritic cell extracts². "
Application References	1. Witmer-Pack MD, et al. 1995. Cell. Immun. 163:157. (IHC, WB) 2. Swiggard WJ, et al. 1995. Cell. Immun. 165:302. (WB, IP) 3. Bonifaz LC, et al. 2004. J. Exp. Med. 199:815. (WB) 4. Yamazaki S, et al. 2002. J. Immunol. 181:6923. (FC) 5. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC)
Description	CD205, also known as DEC-205, is a 205 kD integral membrane protein homologous to the macrophage mannose receptor. It is a type I cell surface protein that belong to the C-type lectin family. CD205 is expressed at high levels by dendritic cells and thymic epithelial cells. It is also expressed by a number of other cell types, such as B lymphocytes, macrophages, Langerhans cells, bone marrow stromal cells, granulocytes, epithelial cells of pulmonary airways, and the capillaries of the brain. CD205 is a novel endocytic receptor used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to specialized antigen processing. It mediates antigen uptake and presentation and cross-presentation to T cells. It has been reported that CD205 acts as a recognition receptor for dying cells, potentially provides an important pathway for the uptake of self-antigen in the intrathymic environment, and is involved in peripheral tolerance. Antibody-mediated antigen-targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity. "
Storage	The antibody solution should be stored undiluted at 4°C.