Purified anti-mouse CD107a (LAMP-1)_详细资料

产品信息

克隆性：多克隆保存条件：蓝冰规格： 200 ug

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Purified anti-mouse CD107a (LAMP-1)参数介绍>>>>

Clone 1D4B
Isotype Rat IgG2a, κ
Reactivity Mouse
Immunogen Mouse embryo 3T3 cells
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography.
Concentration 0.5mg/ml
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Applications
FC - Quality tested
IHC, IP, IF - Reported in the literature
Application Notes
Additional reported applications (for the relevant formats) include: immunoprecipitation¹, immunohistochemical staining^1,2 of acetone-fixed frozen sections, and immunofluorescence microscopy³.
Application References
1. Chen JW, et al. 1985. Arch. Biochem. Biophys. 239:574. (IHC IP)
2. Chen JW, et al. 1986. Biochem. Soc. Symp. 51:97. (IHC)
3. Rohrer J, et al. 1996. J. Cell Biol. 132:565. (IF)
4. Steptoe RJ, et al. 2007. J. Immunol. 178:2094. (FC) PubMed
5. D'Agostino M, et al. 2011. J Cell Sci. 124:3545. PubMed.
"
Description
CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. The mature CD107a is heavily glycosylated from a 40 kD core protein. It is expressed by macrophages, epithelial cells, endothelial cells, and some tumor cells. This molecule is located on the luminal side of lysosomes and has been suggested to play a role in the protection of the lysosome membrane from lysosomal hydrolases. CD107a is a ligand for galaptin. Upon activation, CD107a is transferred to the surface of the cell membrane. It plays a role in cell adhesion and regulation of tumor metastasis and mediates autoimmune disease progression.
Storage The antibody solution should be stored undiluted at 4°C.

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Clone	1D4B
Isotype	Rat IgG2a, κ
Reactivity	Mouse
Immunogen	Mouse embryo 3T3 cells
Formulation	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation	The antibody was purified by affinity chromatography.
Concentration	0.5mg/ml
Recommended Usage	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Applications	FC - Quality tested IHC, IP, IF - Reported in the literature
Application Notes	Additional reported applications (for the relevant formats) include: immunoprecipitation¹, immunohistochemical staining^1,2 of acetone-fixed frozen sections, and immunofluorescence microscopy³.
Application References	1. Chen JW, et al. 1985. Arch. Biochem. Biophys. 239:574. (IHC IP) 2. Chen JW, et al. 1986. Biochem. Soc. Symp. 51:97. (IHC) 3. Rohrer J, et al. 1996. J. Cell Biol. 132:565. (IF) 4. Steptoe RJ, et al. 2007. J. Immunol. 178:2094. (FC) PubMed 5. D'Agostino M, et al. 2011. J Cell Sci. 124:3545. PubMed. "
Description	CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. The mature CD107a is heavily glycosylated from a 40 kD core protein. It is expressed by macrophages, epithelial cells, endothelial cells, and some tumor cells. This molecule is located on the luminal side of lysosomes and has been suggested to play a role in the protection of the lysosome membrane from lysosomal hydrolases. CD107a is a ligand for galaptin. Upon activation, CD107a is transferred to the surface of the cell membrane. It plays a role in cell adhesion and regulation of tumor metastasis and mediates autoimmune disease progression.
Storage	The antibody solution should be stored undiluted at 4°C.