前列腺癌DNA甲基化PCR芯片 Prostate Cancer DNA Methylation PCR Array

Human Prostate Cancer DNA Methylation PCR Array, Signature Panel: EAHS-051Z
The Human Prostate Cancer EpiTect Methyl II Signature PCR Array profiles the methylation status of 22 tumor suppressor gene promoters whose hypermethylation has been reported in the literature to occur frequently in a variety of prostate tumors. Profiling tumor samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also provide insights into the molecular mechanisms and biological pathways behind prostate cancer development and progression, as well as its pathology. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the methylation status of 22 different prostate cancer genes with this DNA methylation PCR array. Both 96-well and 384-well ( 4 X 96 ) formats are available.

Apoptosis & Anti-Apoptosis: APC, CDKN2A, TNFRSF10D.
Calcium Channel Signaling: EDNRB.
Caveolae Protein: CAV1.
Cell Cycle, Growth, Differentiation & Development: APC, CCNA1, CDKN2A, DLC1, RARB, RASSF1.
Cell Adhesion & Migration: APC, CDH1, DLC1, TIMP2.
Cytokine: TNFRSF10D.
Drug Metabolism: GPX3, GSTP1, SLC8.
DNA Methyltransferase: MGMT (AGT).
Extracellular Matrix Remodeling: TIMP2.
Inflammation: PTGS2 (COX2).
Mitogenesis: PTGS2 (COX2).
Nuclear Receptors: AR, RARB.
Oncogene: CAV1.
Protease Inhibitor: TIMP2.
Retinoid Acid Signaling: RARB.
Solute Carrier Family: SLC8.
Transcription Factors & Cofactors: MSX1, PDLIM4 (RIL).
Tumor Suppressor Gene Candidates: APC, CAV1, CDKN2A, RASSF1, SLC8, ZNF185.
WNT Signaling Pathway: APC, DKK3, SFRP1.