胃癌DNA甲基化PCR芯片 Gastric Cancer DNA Methylation PCR Array

Human Gastric Cancer DNA Methylation PCR Array, Signature Panel: EAHS-021Z
The Human Gastric Cancer EpiTect Methyl II Signature PCR Array profiles the methylation status of 22 tumor suppressor gene promoters whose hypermethylation has been reported in the literature to occur frequently in a variety of gastric tumors. Profiling tumor samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also provide insights into the molecular mechanisms and biological pathways behind gastric cancer development and progression, as well as its pathology. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the methylation status of 22 different gastric cancer genes with this DNA methylation PCR array. Both 96-well and 384-well ( 4 X 96 ) formats are available. The EpiTect Methyl II PCR Arrays use the MethylScreen™ Technology provided under license from Orion Genomics, LLC.

Apoptosis & Anti-Apoptosis: FHIT, SFN (14-3-3 sigma).
Cell Adhesion & Migration: CDH1, CDH13, TIMP3.
Cell Cycle, Growth, Differentiation & Development: CCND2 (cyclin D2), CDKN2A, CHFR, FHIT, KLF4, MLH1, RARB, RASSF1, RB1, SFN.
DNA Damage Repair: MLH1, RASSF1, RB1.
DNA Methyltansferase: MGMT (AGT).
Extracellular Matrix Remodeling: LOX, TIMP3.
Histidine Triad Gene Family: FHIT.
Inflammation: PTGS2 (COX2).
Mitogenesis: PTGS2 (COX2).
Nuclear Receptors: RARB.
Proteases Inhibitors: TIMP3.
Protein Kinase: PRKCDBP.
Retinoid Acid Signaling: RARB.
Transcription Factors: KLF4, RB1, RUNX3.
Tumor Suppressor Gene Candidates: CHFR, MLH1, PRKCDBP (SRBC), RASSF1, RB1, RUNX3, SFN, TMEFF2 (HPP1, TPEF).
WNT Signaling: DKK2, SFRP2, SFRP5.