NFkB 信号通路PCR芯片NFkB Signaling Pathway PCR Array

 

Product	Species	Technology	Cat. No.
NFkB Signaling Pathway Plus PCR Array	Human	Gene Expression	PAHS-025Y
NFkB Signaling Pathway PCR Array	Human	Gene Expression	PAHS-025Z
NFkB Signaling Pathway PCR Array	Mouse	Gene Expression	PAMM-025Z
NFkB Signaling Pathway PCR Array	Rat	Gene Expression	PARN-025Z
NFkB Signaling Pathway PCR Array	Rhesus Macaque	Gene Expression	PAQQ-025Z

NFkB 信号通路PCR芯片可用于研究参与NFkB 信号通路的84个关键基因的表达。通过该芯片，可以确定NFkB 信号通路在实验样本中是被激活，YZ还是没有变化。芯片涵盖编码Rel，NFkB和I kB家族，NFkB-效应基因，活化这条通路的细胞外配体及受体，细胞内转导信号的激酶和转录因子。NFkB介导的信号通路调控病毒的复制，自身免疫性疾病，免疫反应，肿瘤形成和凋亡等过程。芯片上还包括16个已经被实验证实的线粒体能量代谢信号通路的生物标识物基因。这16个基因的表达水平可以通过公式计算得出经典NFkB通路活性的分数。利用实时定量PCR，研究者可以方便并且可信地对NFkB信号转导通路相关的基因进行同时检测。

NFκB Pathway: Ligands and Receptors: CD40 (TNFRSF5), CD83, EGFR, FASLG (TNFSF6), IL10, IL1A, IL1B, IL1R1, IL8, LTBR, NOD1 (CARD4), TLR1, TLR2, TLR3, TLR4, TLR6, TLR9, TNF, TNFRSF1A, TNFRSF10A, TNFRSF10B, TNFSF10. Downstream Signaling: BIRC2 (c-IAP2), FADD, IRAK1, IRAK2, IRF1, MYD88, RIPK1, TBK1, TICAM1 (TRIF), TNFAIP3, TRADD, TRAF2, TRAF3, TRAF6. Cytoplasmic Sequestering/Releasing of NFκB: BCL3, CHUK (IKKa), IKBKB, IKBKG, NFKBIA, NFKBIE. Transcription Factors: NFKB1, NFKB2, REL, RELA, RELB. NFκB Responsive Genes: Immune Response: CCL2 (MCP-1), CCL5 (RANTES), CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (GCSF),ICAM1, IFNA1, IFNG, IL8, LTA (TNFB), TNF. Apoptosis: AGT, BCL2A1 (BCL-X), BCL2L1, BIRC3 (c-IAP1). Other Factors Involved in NFκB Pathway: Kinases: AKT1, MAP3K1, RAF1. Transcription Factors: ATF1, EGR1, ELK1, FOS, JUN, STAT1. Other Genes: CARD11, CASP1 (ICE), CASP8, CFLAR (CASPER), HMOX1, MALT1, PSIP1, RHOA, TIMP1. Pathway Activity Signature Genes: BIRC3, CCL20, CD83, CXCL2, CXCL3, ICAM1, IL8, IRF1, NFKB1, NFKBIA, NFKBIE, STX11, TIFA, TNF, TNFAIP2, TNFAIP3.