肝毒性PCR芯片Hepatotoxicity PCR Array

肝毒性PCR芯片检测84个关键基因的表达，这些基因是潜在的肝毒性生物标志物。药物研究的重要难题之一是毒性Z小化，而肝脏在药物代谢中的发挥关键作用，是引起药物相关毒性反应的主要器官，也是毒理学研究的重要目标。在毒性反应模型中持续出现表达上升或下降的基因，可以作为毒性反应的生物标志物，用于预测不良的临床后果。芯片包含与五种主要药物导致的肝毒性疾病相关的潜在生物学标志物基因，这些疾病包括：胆汁淤积、脂肪变性、磷脂、非遗传毒性发生肝致癌和坏死，以及广义的肝毒性药物引起的肝毒性疾病。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测肝毒性反应相关的基因表达。
 

Product	Species	Technology	Cat. No.
Hepatotoxicity PCR Array	Human	Gene Expression	PAHS-093Z
Hepatotoxicity PCR Array	Mouse	Gene Expression	PAMM-093Z
Hepatotoxicity PCR Array	Rat	Gene Expression	PARN-093Z

Cholestasis: ABCB1, ABCB4, ABCC2, ABCC3, ATP8B1, ICAM1, OSTALPHA, PDYN, RDX. Steatosis: Up-Regulated: CD36, FASN, LPL, SCD. Down-Regulated: PPARA, SREBF1. Phospholipidosis: Up-Regulated: ASAH1, FABP1, HPN, LSS, MRPS18B, S100A8, SERPINA3, WIPI1 Down-Regulated: SLC2A3, TAGLN. Regulated: ABCB1, FXC1. Hepatotoxicity: Up-Regulated: ALDOA, APEX1, BTG2, CASP3, CCNG1, CRYL1, DDIT4L, DNAJB11, DNAJC3, GADD4, GCLC, GSR, HMOX1, HYOU1, KRT18, KRT8, NQO1, PLA2G12A, SLC17A3, TXNRD1, YRDC. Down-Regulated: AVPR1A, BHMT, CA3, CXCL12, CYP1A2, FADS1, FMO1, HAO2, IGFALS, MBL2, RB1, THRSP. Regulated: ABCB11, FXC1, MAOB, PYGL. Nongenotoxic Hepatocarcinogenicity: Up-Regulated: ALDOA, APEX1, BTG2, CCNG1, CDKN1A, DDX39A, KRT8, KRT18, MRPS18B, TXNRD1. Necrosis: Up-Regulated: CD68, COL4A1, IL6ST, IPO4, MAP3K6, NUS1, OSMR, PSME3, SERPINE1, SKIL, SLC39A6, TMEM2. Down-Regulated: CDC14B, FAM158A, KIAA1370, L2HGDH, LGR5, MCM10, MLXIPL, RHBG. Regulated: CDKN1A, DDX39A.